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| | Hypercalcemia of malignancy factor (107-139) (human) Basic information |
| Product Name: | Hypercalcemia of malignancy factor (107-139) (human) | | Synonyms: | HypercalceMia of Malignancy Factor (107-139) (huMan), pTH-Related Protein (107-139) (huMan);PTHrP (107-139);parathyroidhormone-relatedprotein-(107-139;PTH-RELATED PROTEIN (107-139) (HUMAN);HYPERCALCEMIA OF MALIGNANCY FACTOR FRAGMENT 107-139;H-THR-ARG-SER-ALA-TRP-LEU-ASP-SER-GLY-VAL-THR-GLY-SER-GLY-LEU-GLU-GLY-ASP-HIS-LEU-SER-ASP-THR-SER-THR-THR-SER-LEU-GLU-LEU-ASP-SER-ARG-OH;hypercalcemia of malignancy factor*fragment 107-1;Parathyroid hormone-related protein (107-139), PTHrP (107-139), Thr-Arg-Ser-Ala-Trp-Leu-Asp-Ser-Gly-Val-Thr-Gly-Ser-Gly-Leu-Glu-Gly-Asp-His-Leu-Ser-Asp-Thr-Ser-Thr-Thr-Ser-Leu-Glu-Leu-Asp-Ser-Arg | | CAS: | 137348-10-8 | | MF: | C142H228N42O58 | | MW: | 3451.58 | | EINECS: | | | Product Categories: | | | Mol File: | 137348-10-8.mol |  |
| | Hypercalcemia of malignancy factor (107-139) (human) Chemical Properties |
| storage temp. | −20°C | | Sequence | Thr-Arg-Ser-Ala-Trp-Leu-Asp-Ser-Gly-Val-Thr-Gly-Ser-Gly-Leu-Glu-Gly-Asp-His-Leu-Ser-Asp-Thr-Ser-Thr-Thr-Ser-Leu-Glu-Leu-Asp-Ser-Arg |
| | Hypercalcemia of malignancy factor (107-139) (human) Usage And Synthesis |
| Uses | Osteostatin (human), a fragment of parathyroid hormone-related protein (PTHrP) 107-139, promotes bone repair in animal models of bone defects and prevents bone erosion in inflammatory arthritis[1]. | | References | [1] Lidia Ibáez, et al. Osteostatin Inhibits M-CSF+RANKL-Induced Human Osteoclast Differentiation by Modulating NFATc1. Int J Mol Sci. 2022 Aug 1;23(15):8551. DOI:10.3390/ijms23158551
[2] C Heras, et al. Osteostatin potentiates the bioactivity of mesoporous glass scaffolds containing Zn2+ ions in human mesenchymal stem cells. Acta Biomater. 2019 Apr 15;89:359-371. DOI:10.1016/j.actbio.2019.03.033 |
| | Hypercalcemia of malignancy factor (107-139) (human) Preparation Products And Raw materials |
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