|
|
| | Boc-GRR-AMC Basic information |
| Product Name: | Boc-GRR-AMC | | Synonyms: | tert-butyl N-[2-[[(2S)-5-(diaminomethylideneamino)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-2-oxoethyl]carbamate;T-BUTYLOXYCARBONYLGLYCYL-L-ARGINYL-L-ARGININE 4-METHYLCOUMARYL-7-AMIDE;BOC-GLY-ARG-ARG-MCA;BOC-GLY-ARG-ARG-AMC;TERT-BUTYLOXYCARBONYL-GLYCYL-L-ARGINYL-L-ARGININE 4-METHYLCOUMARYL-7-AMIDE;L-Argininamide, N-[(1,1-dimethylethoxy)carbonyl]glycyl-L-arginyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-;Boc-Gly-Arg-Arg-AMC trifluoroacetate;Flavivirus protease substrate | | CAS: | 113866-14-1 | | MF: | C29H44N10O7 | | MW: | 644.72 | | EINECS: | | | Product Categories: | Peptide | | Mol File: | 113866-14-1.mol |  |
| | Boc-GRR-AMC Chemical Properties |
| density | 1.408±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | pka | 11.232±0.46(predicted) | | Sequence | {Boc}-Gly-Arg-Arg-{AMC} |
| | Boc-GRR-AMC Usage And Synthesis |
| Uses | Boc-GRR-AMC is a tri-peptide Substrate. Boc-GRR-AMC can be used for a fluorogenic West Nile virus (WNV) substrate, profiling the substrate specificity for the NS2B-NS3 proteases or determining the pH optimum of LdMC activity[1][2]. | | References | [1] Nancy Lee, et al. Characterization of metacaspases with trypsin-like activity and their putative role in programmed cell death in the protozoan parasite Leishmania. Eukaryot Cell. 2007 Oct;6(10):1745-57. DOI:10.1128/EC.00123-07
[2] Manolya Ezgimen, et al.Characterization of the 8-hydroxyquinoline scaffold for inhibitors of West Nile virus serine protease. Antiviral Res. 2012 Apr;94(1):18-24. DOI:10.1016/j.antiviral.2012.02.003 |
| | Boc-GRR-AMC Preparation Products And Raw materials |
|