N-(3-bromophenyl)-4-hydroxy-2-oxo-1H-quinoline-3-carboxamide

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N-(3-bromophenyl)-4-hydroxy-2-oxo-1H-quinoline-3-carboxamide Basic information
Product Name:N-(3-bromophenyl)-4-hydroxy-2-oxo-1H-quinoline-3-carboxamide
Synonyms:N-(3-bromophenyl)-4-hydroxy-2-oxo-1H-quinoline-3-carboxamide;WAY-339696;3-Quinolinecarboxamide, N-(3-bromophenyl)-1,2-dihydro-4-hydroxy-2-oxo-;N-(3-BROMOPHENYL)-4-HYDROXY-2-OXO-1,2-DIHYDRO-3-QUINOLINECARBOXAMIDE;EGFR T790M/L858R-IN-8
CAS:333419-97-9
MF:C16H11BrN2O3
MW:359.17
EINECS:
Product Categories:
Mol File:333419-97-9.mol
N-(3-bromophenyl)-4-hydroxy-2-oxo-1H-quinoline-3-carboxamide Structure
N-(3-bromophenyl)-4-hydroxy-2-oxo-1H-quinoline-3-carboxamide Chemical Properties
Boiling point 624.0±55.0 °C(Predicted)
density 1.711±0.06 g/cm3(Predicted)
pka4.50±1.00(Predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
N-(3-bromophenyl)-4-hydroxy-2-oxo-1H-quinoline-3-carboxamide Usage And Synthesis
UsesEGFR T790M/L858R-IN-8 (compound 9) is a potent inhibitor of EGFR, targeting mutant EGFRT790M/L858R with IC50 of 56.8 μM. The anti-proliferative effect of EGFR T790M/L858R-IN-8 on cancer cell lines A549, A431, and NHI-H1975 is not significant[1].
References[1] Bai F, et al. Discovery of novel selective inhibitors for EGFR-T790M/L858R. Bioorg Med Chem Lett. 2012 Feb 1;22(3):1365-70. DOI:10.1016/j.bmcl.2011.12.067
N-(3-bromophenyl)-4-hydroxy-2-oxo-1H-quinoline-3-carboxamide Preparation Products And Raw materials
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