3-FURANMETHANOL manufacturers
- 3-FURANMETHANOL
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- $15.00 / 1KG
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2021-07-13
- CAS:4412-91-3
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
- 3-FURANMETHANOL
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- $15.00 / 1KG
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2021-07-10
- CAS:4412-91-3
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
- 3-Furancarbinol
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- $10.00 / 1KG
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2020-03-08
- CAS:4412-91-3
- Min. Order: 1KG
- Purity: Min98% HPLC
- Supply Ability: g/kg/ton
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| | 3-FURANMETHANOL Basic information |
| | 3-FURANMETHANOL Chemical Properties |
| Boiling point | 79-80 °C17 mm Hg(lit.) | | density | 1.139 g/mL at 25 °C(lit.) | | refractive index | n20/D 1.484(lit.) | | Fp | 101 °F | | storage temp. | Inert atmosphere,2-8°C | | solubility | Chloroform (Slightly), Methanol (Slightly) | | pka | 14.49±0.10(Predicted) | | form | Liquid | | color | Clear colorless to slightly yellow | | BRN | 106456 | | InChI | InChI=1S/C5H6O2/c6-3-5-1-2-7-4-5/h1-2,4,6H,3H2 | | InChIKey | STJIISDMSMJQQK-UHFFFAOYSA-N | | SMILES | O1C=CC(CO)=C1 | | LogP | 0.300 | | CAS DataBase Reference | 4412-91-3(CAS DataBase Reference) |
| Hazard Codes | Xi,F | | Risk Statements | 10-36/37/38 | | Safety Statements | 16-26-36/37/39-36/37 | | RIDADR | UN 1987 3/PG 3 | | WGK Germany | 3 | | HazardClass | 3.2 | | PackingGroup | III | | HS Code | 29321900 | | Storage Class | 3 - Flammable liquids | | Hazard Classifications | Eye Irrit. 2
Flam. Liq. 3
Skin Irrit. 2
STOT SE 3 |
| | 3-FURANMETHANOL Usage And Synthesis |
| Chemical Properties | Colorless to light yellow liqui | | Uses | 3-Furanmethanol can be used in methods to support gastrointestinal homeostasis. | | General Description | Furan-3-methanol on oxidation with pyridinium chlorochromate yields furan-3-carboxaldehyde. | | Synthesis | General procedure for the synthesis of 3-furanmethanol from ethyl 3-furancarboxylate: To a solution of ethyl 3-furancarboxylate (7) (4.00 g, 28.5 mmol) in anhydrous ethyl ether (Et2O, 140 mL) was added lithium aluminum hydroxide (LiAlH4, 1.62 g, 42.8 mmol) batchwise at 0 °C. The reaction mixture was stirred at room temperature for 45 min. Subsequently, the reaction was quenched by sequential addition of water (H2O, 2 mL), 1 M sodium hydroxide (NaOH, 2 mL) and water (H2O, 6 mL) at 0 °C. The resulting white precipitate was removed by filtration and the solvent was removed by distillation under reduced pressure to give 3-furan methanol (8) (2.60 g, 93%) as a pale yellow oil. Thin layer chromatography (TLC) Rf value was 0.2 (unfolding agent: hexane/ethyl acetate, 4:1).1H NMR (CDCl3) δ: 7.42-7.41 (m, 1H, H2), 7.40-7.39 (m, 1H, H5), 6.44-6.42 (m, 1H, H4), 4.55 (s, 2H, CH2), 1.81 (br s. 1H, OH).13C NMR (CDCl3) δ: 143.3 (C5), 139.9 (C2), 125.1 (C3), 109.9 (C4), 56.1 (CH2). High Resolution Mass Spectrometry (HRMS-EI): m/z [M]+ calculated value for C5H6O2: 98.0368, measured value: 98.0371. | | References | [1] Bulletin of the Chemical Society of Japan, 1983, vol. 56, # 9, p. 2661 - 2679
[2] European Journal of Medicinal Chemistry, 2015, vol. 94, p. 113 - 122
[3] Tetrahedron Letters, 1982, vol. 23, # 31, p. 3115 - 3118
[4] Tetrahedron Asymmetry, 2014, vol. 25, # 8, p. 677 - 689
[5] Journal of Medicinal Chemistry, 1998, vol. 41, # 4, p. 602 - 617 |
| | 3-FURANMETHANOL Preparation Products And Raw materials |
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