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| | Sodium 4-Phenylbutyrate-d11 Basic information |
| | Sodium 4-Phenylbutyrate-d11 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO: 25 mM, | | form | A solid | | color | White to off-white | | Water Solubility | Water: 100 mM |
| | Sodium 4-Phenylbutyrate-d11 Usage And Synthesis |
| Description | Sodium 4-Phenylbutyrate-d11 is intended for use as an internal standard for the quantification of sodium 4-phenylbutyrate by GC- or LC-MS. Sodium 4-phenylbutyrate is a chemical chaperone that has been shown to rescue the trafficking of misfolded proteins. It also weakly blocks histone deacetylase activity (IC50 = 0.4 mM), which results in cell cycle arrest, differentiation, and/or apoptosis of various tumors. Formulations containing sodium 4-phenylbutyrate have been used for the treatment of urea cycle disorders. | | Uses | Phenylbutyrate-d11 (sodium) is deuterium labeled Sodium 4-phenylbutyrate. Sodium 4-phenylbutyrate (4-PBA sodium) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research[1]. | | References | [1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Chang TH, et al. Enhanced growth inhibition by combination differentiation therapy with ligands of peroxisome proliferator-activated receptor-gamma and inhibitors of histone deacetylase in adenocarcinoma of the lung. Clin Cancer Res. 2002 Apr;8(4):1206-12. PMID:11948134
[3] Frouco G, et, al. Sodium phenylbutyrate abrogates African swine fever virus replication by disrupting the virus-induced hypoacetylation status of histone H3K9/K14. Virus Res. 2017 Oct 15;242:24-29. DOI:10.1016/j.virusres.2017.09.009
[4] Park HJ, et al. 4-Phenylbutyric acid protects against lipopolysaccharide-induced bone loss by modulating autophagy in osteoclasts. Biochem Pharmacol. 2018 May;151:9-17. DOI:10.1016/j.bcp.2018.02.019 |
| | Sodium 4-Phenylbutyrate-d11 Preparation Products And Raw materials |
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