| Company Name: |
Wuhan chuang he chemical co. LTD
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| Tel: |
15907120073 |
| Email: |
1261789306@qq.com |
| Products Intro: |
Product Name:BRD3731; BRD-3731;BRD 3731
CAS:2056262-08-7
Package:1g/
|
| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
|
| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:(R)-BRD3731
CAS:2056262-08-7
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:(R)-BRD3731
CAS:2056262-08-7
Package:2mg/RMB 3380;25mg/RMB 12400;50mg/RMB 16167
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| | BRD3731 Basic information |
| Product Name: | BRD3731 | | Synonyms: | BRD3731;BRD3731
(BRD-3731;(R)-BRD3731;5H-Pyrazolo[3,4-b]quinolin-5-one, 3-(2,2-dimethylpropyl)-1,2,4,6,7,8-hexahydro-4,7,7-trimethyl-4-phenyl-, (4R)-;(4R)-3-(2,2-dimethylpropyl)-4,7,7-trimethyl-4-phenyl-2,6,8,9-tetrahydropyrazolo[3,4-b]quinolin-5-one | | CAS: | 2056262-08-7 | | MF: | C24H31N3O | | MW: | 377.52 | | EINECS: | | | Product Categories: | | | Mol File: | 2056262-08-7.mol |  |
| | BRD3731 Chemical Properties |
| Boiling point | 529.3±50.0 °C(Predicted) | | density | 1.15±0.1 g/cm3(Predicted) | | pka | 15.22±0.60(Predicted) | | form | Solid | | color | Light yellow to yellow |
| | BRD3731 Usage And Synthesis |
| Description | BRD3731 is a selective GSK3β inhibitor, with IC50s of 15 nM and 215 nM for GSK3β and GSK3α, respectively. It displays 14-fold selectivity for GSK3β. BRD3731 displays reduced potency towards the GSK3β (D133E), with an IC50 = 53 nM compared to GSK3β (wt) (cf. IC50 = 15 nM). Moreover, BRD3731 inhibits GSK3β with a Kd of 3.3 μM in cellular context. In addition, BRD3731 is a GSK3β- selective inhibitor from patent US20160375006A1, compound example 272. | | Uses | (R)-BRD3731 is a GSK3 inhibitor extracted from patent US20160375006A1, compound example 273, has IC50s of 1.05 and 6.7 μM for GSK3β and GSK3α, respectively[1]. | | IC 50 | GSK3β: 1.05 μM (IC50); GSK3α: 6.7 μM (IC50) | | References | [1] Scolnick E, et, al. Uses of paralog-selective inhibitors of gsk3 kinases. US20160375006A1. |
| | BRD3731 Preparation Products And Raw materials |
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