Raphin1 manufacturers
- Raphin1
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- $30.00
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2026-07-27
- CAS:2022961-17-5
- Purity: 99.39%
- Supply Ability: 10g
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| | Raphin1 Basic information |
| Product Name: | Raphin1 | | Synonyms: | (2E)-2-[(2,3-Dichlorophenyl)methylene]hydrazinecarboximidamide;Raphin1;phosphatase inhibitor;PPP1-R15B inhibitor;RAPHIN1;RAPHIN 1;RAPHIN-1;PHOSPHATASE INHIBITOR; PPP1-R15B INHIBITOR;Hydrazinecarboximidamide, 2-[(2,3-dichlorophenyl)methylene]-, (2E)-;(E)-2-(2,3-Dichlorobenzylidene)hydrazine-1-carboximidamide;Raphin1,Raphin 1,Raphin-1,Phosphatase,inhibit,Inhibitor | | CAS: | 2022961-17-5 | | MF: | C8H8Cl2N4 | | MW: | 231.08 | | EINECS: | | | Product Categories: | | | Mol File: | 2022961-17-5.mol |  |
| | Raphin1 Chemical Properties |
| Boiling point | 360.1±52.0 °C(Predicted) | | density | 1.49±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 125 mg/mL (540.94 mM) | | pka | 8.37±0.50(Predicted) | | form | Solid | | color | White to off-white |
| | Raphin1 Usage And Synthesis |
| Uses | Raphin1 is an orally bioavailable, selective inhibitor of the regulatory phosphatase PPP1R15B (R15B). Raphin1 binds strongly to the R15B-PP1c holophosphatase (Kd=33 nM), and shows ~30-fold selective in binding R15B-PP1c over R15A-PP1c. Raphin1 crosses the blood-brain barrier, and reduces organismal and molecular deficits in a mouse model of a protein misfolding disease[1]. | | in vivo | Raphin1 improves weight of HD82Q mice treated from 4 to ～10 weeks of age with 2 mg/kg of Raphin1 once a day by oral gavage. Raphin1 also decreases SDS-insoluble huntingtin assemblies and nuclear inclusions in the cortex of HD82Q mice[1]. | | storage | Store at -20°C | | References | [1] Krzyzosiak A, et al. Target-Based Discovery of an Inhibitor of the Regulatory Phosphatase PPP1R15B. Cell. 2018 Aug 23;174(5):1216-1228.e19. DOI:10.1016/j.cell.2018.06.030 |
| | Raphin1 Preparation Products And Raw materials |
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