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| | Anti-Histone Deacetylase 5 (HDAC5) antibody, Mouse monoclonal Basic information |
| | Anti-Histone Deacetylase 5 (HDAC5) antibody, Mouse monoclonal Chemical Properties |
| storage temp. | -20°C | | form | buffered aqueous solution | | biological source | mouse |
| WGK Germany | nwg | | Storage Class | 12 - Non Combustible Liquids |
| | Anti-Histone Deacetylase 5 (HDAC5) antibody, Mouse monoclonal Usage And Synthesis |
| Uses | Anti-Histone Deacetylase 5 (HDAC5) antibody, Mouse monoclonal has been used in:
- western blotting
- immunostaining
- enzyme-linked immunosorbent assay (ELISA)
- immunocytochemistry
- immunoprecipitation
| | General Description | Monoclonal Anti-Histone Deacetylase 5 (HDAC5) (mouse IgG1 isotype) is derived from the HDAC5-35 hybridoma produced by the fusion of mouse myeloma cells (NS1) and splenocytes from BALB/c mice immunized with a synthetic peptide. Mammalian HDACs can be divided into three classes according to sequence homology. Class II consists of the yeast Hda1-like proteins HDAC4, HDAC5, HDAC6, HDAC7, HDAC9 and HDAC10. Histone deacetylase 5 (HDAC5) is a histone deacetylase, located on human chromosome 17q21. | | Biochem/physiol Actions | Histone deacetylase 5 (HDAC5) promotes progression of the cell cycle, cell proliferation and apoptosis. HDAC5 activity is important for the differentiation of muscle cells by binding, through its N-terminal domain, to the myocyte enhancer factor-2 (Mef2) protein, thus repressing expression of MEF2 downstream genes. Overexpression of HDAC5 in different cancer cells suppresses their growth by induction of apoptosis in a p53-independent manner. Reduced expression of the protein is observed in colon cancer and acute myeloid leukemia. |
| | Anti-Histone Deacetylase 5 (HDAC5) antibody, Mouse monoclonal Preparation Products And Raw materials |
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