TPN729MA manufacturers
- TPN729MA
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- $2130.00
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2026-07-15
- CAS:1422955-52-9
- Purity:
- Supply Ability: 10g
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| | TPN729MA Basic information |
| | TPN729MA Chemical Properties |
| form | Solid | | color | White to off-white |
| | TPN729MA Usage And Synthesis |
| Uses | TPN729MA (TPN729 maleate) is a selective phosphodiesterase type 5 (PDE5) inhibitor with an IC50 value of 2.28 nM. TPN729MA affects erectile function and it can be used for the research of erectile dysfunction[1]. | | in vivo | TPN729MA (1.25, 2.5 and 5.0 mg/kg; intraduodenal injection, once) increases intracavernous pressure/blood pressure (ICP/BP) with the dose of 5.0 mg/kg at all time points and with the dose of 2.5 mg/kg at 75, 90, 105, and 120 minutes time points[1].
TPN729MA (5.0 μg/kg, i.v., once) significantly increases ICP and ICP/BP of male Beagle dogs[1]. | Animal Model: | Male Sprague-Dawley rats with corpora cavernosa complete exposure[1] | | Dosage: | 1.25, 2.5 and 5.0 mg/kg | | Administration: | Intraduodenal (i.d.) injection; 1.25, 2.5 and 5.0 mg/kg, once | | Result: | Dose-dependently increased the maximum intracavernous pressure (ICP) and ICP/blood pressure (BP). |
| | IC 50 | PDE5: 2.28 nM (IC50); PDE6: 45.2 nM (IC50); PDE1: 566 nM (IC50); PDE4: 834 nM (IC50); PDE11: 6090 nM (IC50) | | References | [1] Wang Z, et al. The selectivity and potency of the new PDE5 inhibitor TPN729MA. J Sex Med. 2013 Nov;10(11):2790-7. DOI:10.1111/jsm.12285 |
| | TPN729MA Preparation Products And Raw materials |
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