Sphingosine Kinase Inhibitor, SKI-I manufacturers
- SKI-I
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2026-07-15
- CAS:306301-68-8
- Purity:
- Supply Ability: 10g
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| | Sphingosine Kinase Inhibitor, SKI-I Basic information |
| Product Name: | Sphingosine Kinase Inhibitor, SKI-I | | Synonyms: | Sphingosine Kinase Inhibitor, SKI-I;SKI-I;1H-Pyrazole-3-carboxylic acid, 5-(2-naphthalenyl)-, 2-[(2-hydroxy-1-naphthalenyl)methylene]hydrazide;SKI-I, Sphingosine Kinase Inhibitor | | CAS: | 306301-68-8 | | MF: | C25H18N4O2 | | MW: | 406.44 | | EINECS: | | | Product Categories: | | | Mol File: | 306301-68-8.mol |  |
| | Sphingosine Kinase Inhibitor, SKI-I Chemical Properties |
| density | 1.33±0.1 g/cm3(Predicted) | | solubility | DMSO : 100 mg/mL (246.04 mM; Need ultrasonic) | | pka | 8.20±0.50(Predicted) | | form | Solid | | color | Off-white to light yellow |
| | Sphingosine Kinase Inhibitor, SKI-I Usage And Synthesis |
| Uses | SKI-I is a potent and selective inhibitor of human sphingosine kinase (SK), with an IC50 of 1.2 μM for ST-hSK. SKI-I also inhibits hERK2 (IC50=11 μM). SKI-I induces apoptosis in tumor cell lines[1][2]. | | References | [1] French KJ, et, al. Discovery and evaluation of inhibitors of human sphingosine kinase. Cancer Res. 2003 Sep 15;63(18):5962-9. PMID:14522923
[2] Sharma AK, et, al. Synthesis and bioactivity of sphingosine kinase inhibitors and their novel aspirinyl conjugated analogs. Eur J Med Chem. 2010 Sep;45(9):4149-56. DOI:10.1016/j.ejmech.2010.06.005 |
| | Sphingosine Kinase Inhibitor, SKI-I Preparation Products And Raw materials |
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