BETd-246

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Company Name: Shanghai finete Pharmaceutical Co., Ltd.
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Products Intro: Product Name:BETd-246
CAS:2140289-17-2
Purity:98% Package:1mg;5mg; 10mg;50mg;
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:BETd-246
CAS:2140289-17-2
Purity:98.00% Package:10 mg；100 mg；200 mg；25 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Wuhan Fortuna Chemical Co., Ltd
Tel: +86-27-59207850
Email: info@fortunachem.com
Products Intro: Product Name:BETd-246
CAS:2140289-17-2
Purity:98%min Package:1mg;USD
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:BETd-246
CAS:2140289-17-2
Purity:98% Package:5mg Remarks:V3578
Company Name: Aladdin Scientific
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Email: tp@aladdinsci.com
Products Intro: Product Name:BETd-246
CAS:2140289-17-2
Purity:98% Package:$650.9/5mg;$950.9/10mg;$1950.9/25mg;$2950.9/50mg;Bulk package Remarks:98%

BETd-246 manufacturers

  • BETd-246
  • BETd-246 pictures
  • 2026-07-03
  • CAS:2140289-17-2
  • Min. Order: 1mg
  • Purity: 98%min
  • Supply Ability: 50mg
BETd-246 Basic information
Product Name:BETd-246
Synonyms:BETd-246;BETd-246 (BETd 246;9H-Pyrimido[4,5-b]indole-2-carboxamide, 4-[(3-cyclopropyl-1-ethyl-1H-pyrazol-5-yl)amino]-7-(3,5-dimethyl-4-isoxazolyl)-N-[3-[2-[2-[3-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]propoxy]ethoxy]ethoxy]propyl]-6-methoxy-;4-[(3-cyclopropyl-1-ethyl-1H-pyrazol-5-yl)amino]-7-(3,5-dimethyl-1,2-oxazol-4-yl)-N-(3-{2-[2-(3-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}propoxy)ethoxy]ethoxy}propyl)-6-methoxy-9H-pyrimido[4,5-b]indole-2-carboxamide;4-[(3-Cyclopropyl-1-ethyl-1H-pyrazol-5-yl)amino]-7-(3,5-dimethyl-4-isoxazolyl)-N-[3-[2-[2-[3-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]propoxy]ethoxy]ethoxy]propyl]-6-methoxy-9H-pyrimido[4,5-b]indole-2-carboxamide
CAS:2140289-17-2
MF:C48H55N11O10
MW:946.02
EINECS:
Product Categories:
Mol File:2140289-17-2.mol
BETd-246 Structure
BETd-246 Chemical Properties
density 1.51±0.1 g/cm3(Predicted)
storage temp. Store at -20°C, stored under nitrogen
solubility DMSO : 200 mg/mL (211.41 mM; Need ultrasonic)
form Solid
pka10.75±0.40(Predicted)
color Light yellow to yellow
Safety Information
MSDS Information
BETd-246 Usage And Synthesis
UsesBETd-246 is a second-generation and PROTAC-based BET bromodomain (BRD) inhibitor connected by ligands for Cereblon and BET, exhibiting superior selectivity, potency and antitumor activity[1].
in vivo

BETd-246 (5 mg/kg, IV, 3 times per week for 3 weeks) treatment effectively inhibits WHIM24 tumor growth, similar to the antitumor activity of BETi-211 with higher dosage and more frequently administration. The treatment of 10 mg/kg induces partial tumor regression during treatment without apparent toxicity. BETd-246 has very limited drug exposure in the xenograft tumor tissue in MDA-M-231and MDA-MB-468 models[1].

Animal Model:“Washington Human in Mouse (WHIM)” (PDX) model developed from a patient with treatment-resistant breast cancer (ESRE380Q, PR- and HER2-))[1].
Dosage:5, 10 mg/kg
Administration:IV, 3 times per week for 3 weeks.
Result:Effectively inhibited WHIM24 tumor growth.
References[1] Bai L, et al. Targeted Degradation of BET Proteins in Triple-Negative Breast Cancer. Cancer Res. 2017 May 1;77(9):2476-2487. DOI:10.1158/0008-5472.CAN-16-2622
BETd-246 Preparation Products And Raw materials
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