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| | TRAF-3 ANTIBODY Chemical Properties |
| | TRAF-3 ANTIBODY Usage And Synthesis |
| Source | Rabbit | | Reactivity | Human;Mouse;Rat;Monkey | | Background | TRAFs are a family of multifunctional adaptor proteins that bind to surface receptors and recruit additional proteins to form multiprotein signaling complexes capable of promoting cellular responses. Members of the TRAF family share a common carboxy-terminal "TRAF domain", which mediates interactions with associated proteins; many also contain amino-terminal Zinc/RING finger motifs. The first TRAFs identified, TRAF1 and TRAF2, were found by virtue of their interactions with the cytoplasmic domain of TNF-receptor 2. The six known TRAFs act as adaptor proteins for a wide range of cell surface receptors and participate in the regulation of cell survival, proliferation, differentiation, and stress responses. | | References | [1] Arch, R.H. et al. (1998) Genes Dev 12, 2821-30.
[2] Chung, J.Y. et al. (2002) J Cell Sci 115, 679-88.
[3] Bradley, J.R. and Pober, J.S. (2001) Oncogene 20, 6482-91.
[4] Rothe, M. et al. (1994) Cell 78, 681-92. |
| | TRAF-3 ANTIBODY Preparation Products And Raw materials |
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