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| | 1-BOC-3-METHANESULFONYLOXYPYRROLIDINE Basic information |
| Product Name: | 1-BOC-3-METHANESULFONYLOXYPYRROLIDINE | | Synonyms: | 1-(tert-Butoxycarbonyl)pyrrolidin-3-yl methanesulfonate;1-BOC-3-METHANESULFONYLOXYPYRROLIDINE;3-METHANESULFONYLOXY-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;(R)-3-(Methylsulphonyloxy)pyrrolidine;(R)-3-(Methylsulphonyloxy)pyrrolidine, N-BOC protected;138883;(R)-3-(Methylsulphonyloxy)pyrrolidine, N-BOC protected 95+%;2-(3-pyrrolidinyloxysulfonyl)acetic acid tert-butyl ester | | CAS: | 141699-57-2 | | MF: | C10H19NO5S | | MW: | 265.33 | | EINECS: | | | Product Categories: | | | Mol File: | 141699-57-2.mol |  |
| | 1-BOC-3-METHANESULFONYLOXYPYRROLIDINE Chemical Properties |
| Boiling point | 392.9±31.0 °C(Predicted) | | density | 1.25±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | -3.65±0.40(Predicted) | | form | solid | | InChI | 1S/C10H19NO5S/c1-10(2,3)15-9(12)11-6-5-8(7-11)16-17(4,13)14/h8H,5-7H2,1-4H3/t8-/m1/s1 | | InChIKey | KWQRKOSMSFLBTJ-MRVPVSSYSA-N | | SMILES | CC(C)(C)OC(=O)N1CC[C@H](C1)OS(C)(=O)=O |
| Hazard Codes | Xi,T | | Risk Statements | 25 | | Safety Statements | 45 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 2933998090 | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Acute Tox. 3 Oral |
| | 1-BOC-3-METHANESULFONYLOXYPYRROLIDINE Usage And Synthesis |
| Synthesis | GENERAL STEPS: To a stirred solution of 1-tert-butoxycarbonyl-3-hydroxypyrrolidine (16 g, 85.4 mmol) and triethylamine (19 mL, 129 mmol) in 130 mL of dichloromethane was added slowly and dropwise to a solution of methanesulfonyl chloride (10 mL, 129 mmol) in 20 mL of dichloromethane at 0 °C. After the dropwise addition was completed, the reaction mixture was continued to be stirred at room temperature for 2.5 hours. Upon completion of the reaction, the reaction was quenched with saturated aqueous sodium bicarbonate and extracted with dichloromethane. The organic phases were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give tert-butyl 3-methanesulfonyloxypyrrolidine-1-carboxylate (22.7 g, 100% yield) as a yellow solid. | | References | [1] Patent: WO2013/97773, 2013, A1. Location in patent: Paragraph 0150
[2] Patent: US2016/168156, 2016, A1. Location in patent: Paragraph 0494; 0495
[3] Patent: KR2016/103390, 2016, A. Location in patent: Paragraph 0099; 0102
[4] Patent: CN107474024, 2017, A. Location in patent: Paragraph 0385; 0389; 0390; 0391
[5] Patent: US2016/200730, 2016, A1. Location in patent: Paragraph 0278; 0279 |
| | 1-BOC-3-METHANESULFONYLOXYPYRROLIDINE Preparation Products And Raw materials |
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