(R)-(-)-α-Methylhistamine dihydrobromide

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(R)-(-)-α-Methylhistamine dihydrobromide manufacturers
(R)-(-)-α-Methylhistamine dihydrobromide Basic information
Product Name:(R)-(-)-α-Methylhistamine dihydrobromide
Synonyms:(R)-(-)-α-Methylhistamine dihydrobromide;(αR)?-α-?Methyl-1H-?imidazole-?5-?ethanamine Hydrobromide;(R)()αMethylhistamine dihydrobromide,(R) ( ) α Methylhistamine dihydrobromide
CAS:868698-49-1
MF:C6H12BrN3
MW:206.09
EINECS:
Product Categories:
Mol File:868698-49-1.mol
(R)-(-)-α-Methylhistamine dihydrobromide Structure
(R)-(-)-α-Methylhistamine dihydrobromide Chemical Properties
storage temp. Desiccate at RT
form White solid.
color Brown to reddish brown
Water Solubility Soluble to 100 mM in water
Safety Information
MSDS Information
(R)-(-)-α-Methylhistamine dihydrobromide Usage And Synthesis
Uses(αR)-α-Methyl-1H-imidazole-5-ethanamine Hydrobromide is a histamine H3 agonist and an inhibitor of histamine synthesis.
in vivo

Pretreatment with (R)-(-)-α-Methylhistamine dihydrobromide (RAMH; 10 mg/kg; i.p.; 60 min before training) reverses Propofol‐induced (25 mg/kg; i.p.; 30 min before training) memory retention[5].
(R)-(-)-α-Methylhistamine dihydrochloride (6.3 mg/kg; i.p.) significantly decreases the steady-state t-MH level in the mouse brain, whereas these compounds produced no significant changes in the HA level[3].

Animal Model:Male Sprague‐Dawley rats (10-12 week)[3]
Dosage:10 mg/kg
Administration:IP; 60 min before training
Result:Reversed propofol‐induced memory retention.
IC 50H3 Receptor: 50.3 nM (Kd)
storageDesiccate at RT
(R)-(-)-α-Methylhistamine dihydrobromide Preparation Products And Raw materials
Tag:(R)-(-)-α-Methylhistamine dihydrobromide(868698-49-1) Related Product Information
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