JNJ 28871063 hydrochloride

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Company Name: TargetMol Chemicals Inc.
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Products Intro: Product Name:JNJ28871063 hydrochloride
CAS:944342-90-9
Package:10mg;
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Products Intro: Product Name:JNJ 28871063 hydrochloride
CAS:944342-90-9
Purity:>=97%(HPLC) Package:$208.9/10mg;$869.9/50mg;Bulk package Remarks:97%(HPLC)
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Products Intro: Product Name:JNJ 28871063 hydrochloride
CAS:944342-90-9
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Products Intro: CAS:944342-90-9
Purity:97% Package:5g,10g,25g
Company Name: Shanghai YuanYe Biotechnology Co., Ltd.  
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Products Intro: Product Name:JNJ 28871063 hydrochloride
CAS:944342-90-9
Package:10mg;50mg Remarks:V65813

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JNJ 28871063 hydrochloride Basic information
Product Name:JNJ 28871063 hydrochloride
Synonyms:JNJ28871063 hydrochloride,JNJ-28871063 hydrochloride
CAS:944342-90-9
MF:C24H28Cl2N6O3
MW:519.43
EINECS:
Product Categories:
Mol File:944342-90-9.mol
JNJ 28871063 hydrochloride Structure
JNJ 28871063 hydrochloride Chemical Properties
storage temp. Store at -20°C
solubility Soluble to 50 mM in DMSO
form Powder
color Light yellow to yellow
Safety Information
MSDS Information
JNJ 28871063 hydrochloride Usage And Synthesis
UsesJNJ 28871063 Hydrochloride is a nonquinazoline Pan-ErbB kinase inhibitor that crosses the blood-brain barrier and displays efficacy against intracranial tumors.
in vivo

JNJ28871063 hydrochloride (100 mg/kg/day; Oral; for 30 days) shows significant inhibition of tumor growth (TGI=71%)[1].
JNJ28871063 hydrochloride produces a significant inhibition of tumor growth at 100 mg/kg (TGI=66.8%) in an A431 human tumor xenograft model[1].

Animal Model:Nude mice bearing N87 tumor xenografts[1]
Dosage:100 mg/kg
Administration:Oral; daily for 30 days
Result:Showed significant inhibition of tumor growth (TGI=71%).
IC 50ErbB1: 22 nM (IC50); ErbB2: 38 nM (IC50); ErbB4: 21 nM (IC50)
storageDesiccate at +4°C
JNJ 28871063 hydrochloride Preparation Products And Raw materials
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