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BOC Sciences |
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MW-150 dihydrochloride dihydrate manufacturers
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| | MW-150 dihydrochloride dihydrate Basic information |
| | MW-150 dihydrochloride dihydrate Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO : 20.83 mg/mL (42.47 mM) |
| | MW-150 dihydrochloride dihydrate Usage And Synthesis |
| Uses | MW-150 dihydrochloride dihydrate (MW01-18-150SRM dihydrochloride dihydrate) is a selective, CNS penetrant, and orally active inhibitor of p38α MAPK with a Ki of 101 nM. MW-150 dihydrochloride dihydrate (MW01-18-150SRM dihydrochloride dihydrate) inhibits the ability of the endogenous p38α MAPK to phosphorylate an endogenous substrate MK2 in activated glia[1]. | | in vivo | MW-150 dihydrochloride dihydrate (2.5 mg/kg; oral daily for 3 4 months) improves the APP/PS1 transgenic (Tg) mice performance in radial arm water maze (RAWM) and contextual fear conditioning tests[1].
MW-150 dihydrochloride dihydrate (2.5 mg/kg; given i.p.; daily for 14 days) treatment in APPNLh/NLh × PSP264L/P264L knock-in mouse (with no overexpression of the amyloid precursor protein) exhibits RAWM behavior indistinguishable from WT mice[1]. | | IC 50 | p38α: 101 nM (Ki) | | References | [1] Roy SM, et al. Targeting human central nervous system protein kinases: An isoform selective p38αMAPK inhibitor that attenuates disease progression in Alzheimer's disease mouse models. ACS Chem Neurosci. 2015 Apr 15;6(4):666-80. DOI:10.1021/acschemneuro.5b00002 |
| | MW-150 dihydrochloride dihydrate Preparation Products And Raw materials |
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