Mca-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770(667-675)-Lys(Dnp) ammonium acetate salt
| 中文名称 | Mca-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770(667-675)-Lys(Dnp) ammonium acetate salt |
|---|---|
| 中文同义词 | MCA-(ASN670,LEU671)-AMYLOID Β/A4 PROTEIN PRECURSOR770(667-675)-LYS(DNP) AMMONIUM ACETATE SALT;荧光底物多肽Mca-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (667-675)-Lys(Dnp);7-甲氧基香豆素-SEVNLDAEFK(二硝基苯基)酰胺(BACE-1 荧光底物肽;607438 |
| 英文名称 | Mca-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770(667-675)-Lys(Dnp) ammonium acetate salt |
| 英文同义词 | Mca-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770(667-675)-Lys(Dnp) ammonium acetate salt;Mca-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (667-675)-Lys(Dnp) ammonium;L-Lysine, N-[2-(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-seryl-L-α-glutamyl-L-valyl-L-asparaginyl-L-leucyl-L-α-aspartyl-L-alanyl-L-α-glutamyl-L-phenylalanyl-N6-(2,4-dinitrophenyl)-;Mca-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (667-675)-Lys(Dnp);Mca-(Asn???,Leu??1)-Amyloid β/A4 Protein Precursor??? (667-675)-Lys(Dnp) ammonium acetate salt;Mca-(Asn???,Leu???)-Amyloid β/A4 Protein Precursor??? (667-675)-Lys(Dnp) ammonium acetate salt;Mca-(Asn670,Leu671)-Amyloid beta/A4 Protein Precursor770 (667-675)-Lys(Dnp) ammonium acetate salt;Mca-(Asn???,Leu??1)-APP??? (667-675)-Lys(Dnp) |
| CAS号 | 1802078-31-4 |
| 分子式 | C68H88N14O27 |
| 分子量 | 1533.52 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1802078-31-4.mol |
| 结构式 |  |
Mca-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770(667-675)-Lys(Dnp) ammonium acetate salt 性质
| 沸点 | 1881.2±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.404±0.06 g/cm3(Predicted) |
| 酸度系数(pKa) | 3.37±0.10(Predicted) |
| 序列 | {Mca}-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-{Lys(Dnp)} |
Mca-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770(667-675)-Lys(Dnp) ammonium acetate salt 用途与合成方法
Mca-SEVNLDAEFK(Dnp) 是一种 β 分泌酶 1 (BACE-1) 肽 FRET 底物，含有淀粉样前体蛋白 (APP) β 分泌酶裂解位点的“瑞典”Lys-Met/Asn-Leu 突变。Mca-SEVNLDAEFK(Dnp) 的 -Leu-Asp- 处的裂解从 2,4-二硝基苯基 (Dnp) 内部猝灭剂的邻近猝灭效应中释放出高荧光的 7-甲氧基香豆素 (Mca) 片段，导致荧光强度大幅且易于检测的增加。