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| | NVP-AAM077 Basic information |
| Product Name: | NVP-AAM077 | | Synonyms: | CS-1513;PEAQX(NVP-AAM 077);3-dioxo-5-quinoxalinyl)methyl] phosphonic acid tetrasodium hydrate;PEAQX tetrasodium hydrate
[[[(1S)-1-(4-Bromophenyl)ethyl]amino](1;PEAQX; NVP-AAM077 TETRASODIUM HYDRATE; NVP-AAM 077 TETRASODIUM HYDRATE; PEAQX TETRASODIUM HYDRATE[[[(1S)-1-(4-BROMOPHENYL)ETHYL]AMINO](1;2;3;4-TETRAHYDRO-2;3-DIOXO-5-QUINOXALINYL)METHYL] PHOSPHONIC ACID TETRASODIUM HYDRATE;NVP-AAM077 Tetrasodium Hydrate - CAS 459836-30-7 - Calbiochem;PEAQX;[[[(1s)-1-(4-bromophenyl)ethyl]amino](1,2,3,4-tetrahydro-2,3-dioxo-5-quinoxalinyl)methyl]phosphonic acid tetrasodium hydrate | | CAS: | 459836-30-7 | | MF: | C17H17BrN3O5P | | MW: | 454.21 | | EINECS: | | | Product Categories: | API | | Mol File: | 459836-30-7.mol |  |
| | NVP-AAM077 Chemical Properties |
| density | 1.639±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | DMSO: soluble10mg/mL, clear | | form | White solid | | pka | 1.19±0.10(Predicted) | | color | white to beige | | Water Solubility | Soluble in water (10mM) | | InChIKey | AJYMYLQKBICSOD-ULMLUZALSA-J |
| Hazard Codes | Xn | | Risk Statements | 22-36/37/38 | | Safety Statements | 26 | | WGK Germany | 3 |
| | NVP-AAM077 Usage And Synthesis |
| Uses | PEAQX tetrasodium hydrate has been used N-methyl-D-aspartate (NMDA) receptor 2A (NR2A) antagonist in rats and mice. | | Biochem/physiol Actions | PEAQX is more specific for N-methyl-D-aspartate (NMDA) receptor 2A (NR2A) than N-methyl-D-aspartate (NMDA) receptor 2B (NR2B) and induces striatal apoptosis. It is less potent in activating caspase-3 than its stereomer NVP-AAM007. | | Enzyme inhibitor | This potent NMDA receptor antagonist and experimental anticonvulsant (FW = 542.14 g/mol), also known as NVP-AAM077 and tetrasodium [[[(1S)-1-(4-bromophenyl)ethyl]amino](1,2,3,4-tetrahydro-2,3-dioxo-5- quinoxalinyl)methyl] phosphonate, is a competitive antagonist for ionotropic glutamate [N-methyl-D-aspartate] receptors (or GluN receptors). Although originally described as being 100x more active against GluN1/GluN2A receptors versus GluN1/GluN2B receptors, later studies revealed only a 5x difference in affinity. There is no difference in the steady-state levels of inhibition produced by NVP-AAM077 when it was either preapplied or coapplied with glutamate. | | storage | -20°C |
| | NVP-AAM077 Preparation Products And Raw materials |
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