(+/-)-2-Propylpiperidine hydrochloride*

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Company Name: UHN Shanghai Research & Development Co., Ltd.  
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(+/-)-2-Propylpiperidine hydrochloride* Basic information
Product Name:(+/-)-2-Propylpiperidine hydrochloride*
Synonyms:Piperidine, 2-propyl-, hydrochloride (1:1);Coniine hydrochloride in methanol;Coniine hydrochloride-RM;Coniine hydrochloride, 10 mM in DMSO;(±)-Coniine (hydrochloride);(+/-)-2-Propylpiperidine hydrochloride*
CAS:15991-59-0
MF:C8H18ClN
MW:163.68822
EINECS:
Product Categories:
Mol File:15991-59-0.mol
(+/-)-2-Propylpiperidine hydrochloride* Structure
(+/-)-2-Propylpiperidine hydrochloride* Chemical Properties
Melting point ~210 °C(lit.)
storage temp. Inert atmosphere,Room Temperature
form Solid
color White to off-white
Safety Information
Hazard Codes Xi
Risk Statements 36
Safety Statements 26
WGK Germany -
MSDS Information
(+/-)-2-Propylpiperidine hydrochloride* Usage And Synthesis
Uses(±)-Coniine hydrochloride (2-Propylpiperidine hydrochloride) is a potent nAChR agonist with an EC50 value of 0.3 mM. (±)-Coniine hydrochloride shows acute toxicity with an LD50 value of 7.7 mg/kg[1].
in vivo

(±)-Coniine hydrochloride (compound 1) (0.05 mg-0.2 mg; i.v.) shows acute toxicity with an LD50 value of 7.7 mg/kg[1].

Animal Model:15-20 g, Swiss-Webster male mice[1]
Dosage:0.05 mg-0.2 mg
Administration:I.v.
Result:Clinical signs was almost immediate after injection, beginning with piloerection, tail flicking, and rapidly progressing to intention tremors, clonic convulsions, muscular weakness, lateral recumbency, and death; shows acute toxicity with an LD50 value of 7.7 mg/kg.
References[1] Lee ST, et al. Stereoselective potencies and relative toxicities of coniine enantiomers. Chem Res Toxicol. 2008 Oct;21(10):2061-4. DOI:10.1021/tx800229w
(+/-)-2-Propylpiperidine hydrochloride* Preparation Products And Raw materials
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