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| | 4-CYANOBENZENESULFONYL CHLORIDE 97 Basic information |
| | 4-CYANOBENZENESULFONYL CHLORIDE 97 Chemical Properties |
| Melting point | 107-111 °C (lit.) | | Boiling point | 90-95 °C(Press: 3-4 Torr) | | density | 1.53±0.1 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | form | powder to crystal | | color | White to Light yellow | | Sensitive | Moisture Sensitive | | BRN | 777939 | | CAS DataBase Reference | 49584-26-1(CAS DataBase Reference) |
| | 4-CYANOBENZENESULFONYL CHLORIDE 97 Usage And Synthesis |
| Chemical Properties | Light orange solid | | Uses | 4-Cyanobenzenesulfonyl chloride is a useful research chemical compound used in the preparation of phenyldiazenyl-sulfonamides as aromatase inhibitors. | | Synthesis | N-Chlorosuccinimide (NCS, 1.778 g, 13.32 mmol) was slowly added to a suspension of 4-(benzylthio)benzonitrile (1 g, 4.44 mmol) dissolved in acetic acid (AcOH, 10 mL) and water (3.5 mL) at 0 °C. The reaction mixture was stirred at room temperature for 2 hours. After completion of the reaction, the reaction mixture was diluted with ethyl acetate (EtOAc), washed sequentially with water and saturated brine, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography using a hexane solution of 15%-20% ethyl acetate as eluent to give a white solid. The resulting solid was washed with hexane and dried under reduced pressure to give 4-cyanobenzenesulfonyl chloride (0.701 g, 3.48 mmol, 78% yield) as a white solid. The structure of the product was confirmed by 1H NMR (300 MHz, CDCl3): δ 7.91-7.97 (2H, m), 8.15-8.21 (2H, m). | | References | [1] Patent: WO2018/30550, 2018, A1. Location in patent: Paragraph 0605
[2] Tetrahedron Letters, 2017, vol. 58, # 23, p. 2244 - 2247 |
| | 4-CYANOBENZENESULFONYL CHLORIDE 97 Preparation Products And Raw materials |
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