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| | ANISODAMINE HYDROBROMIDE Basic information |
| | ANISODAMINE HYDROBROMIDE Chemical Properties |
| Melting point | 176-178 °C | | form | Solid | | color | White to off-white |
| | ANISODAMINE HYDROBROMIDE Usage And Synthesis |
| Uses | Anisodamine hydrobromide (6-Hydroxyhyoscyamine hydrobromide), a belladonna alkaloid, is a non-subtype-selective muscarinic and a nicotinic cholinoceptor antagonist. Anisodamine hydrobromide shows antioxidant, anti-inflammatory properties[1][2]. | | in vivo | Anisodamine hydrobromide (50 mg/kg; i.p.; 72 hours) markedly decreases the mortality to 20%[2]. | Animal Model: | LPS-Induced Shock Mice[2] | | Dosage: | 50 mg/kg | | Administration: | I.p. | | Result: | Markedly decreased the mortality to 20%.
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| | References | [1] Eisenkraft A. Possible role for anisodamine in organophosphate poisoning. Br J Pharmacol. 2016;173(11):1719-1727. DOI:10.1111/bph.13486
[2] Liu C, et al. Antishock effect of anisodamine involves a novel pathway for activating alpha7 nicotinic acetylcholine receptor. Crit Care Med. 2009;37(2):634-641. DOI:10.1097/CCM.0b013e31819598f5 |
| | ANISODAMINE HYDROBROMIDE Preparation Products And Raw materials |
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