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ChemicalBook > Product Catalog >Analytical Chemistry >Analysis reagents >Ion chromatography reagents >OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS)

OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS)

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OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS) Suppliers list
Company Name: Guangzhou Tosun Pharmaceutical Ltd
Tel: +86-020-61855200-902 +8618124244216
Email: info@upharm.cn
Products Intro: Product Name:Omeprazole(Esomeprazole-magnesium) EP Impurity D
CAS:88546-55-8
Purity:95%+ Package:5mg;|10mg;|50mg
Company Name: Hefei Lbao Physical & Chemical Science Co.,Ltd
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Products Intro: Product Name:OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS)
CAS:88546-55-8
Purity:98% Package:1kg;
Company Name: ATK CHEMICAL COMPANY LIMITED
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Email: ivan@atkchemical.com
Products Intro: CAS:88546-55-8
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G
Company Name: career henan chemical co
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Products Intro: Product Name:OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS)
CAS: 88546-55-8
Purity:99% Package:1KG;1USD
Company Name: Standardpharm Co. Ltd.
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Products Intro: Product Name:Esomeprazole Impurity 4
CAS:88546-55-8
Purity:0.99 Package:10mg;25mg;50mg;100mg

OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS) manufacturers
OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS) Basic information
Product Name:OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS)
Synonyms:Esomeprazole sodium D(H168/66);Esomeprazole Sodium?CP Impurity Ⅰ;5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]sulfonyl]benzimidazole;EsoMeprazol iMpurity D;OMeprazole IMpurity-D(EP) (USP R C A);6-Methoxy-2-((4-Methoxy-3,5-diMethylpyridin-2-yl)Methylsulfonyl)-1H-benzo[d]iMidazole;OMeprazole EP IMpurity D;5-Methoxy-2-[[(4-Methxoy-3,5-diMethylpyridin-2-yl)Methyl]sulfonyl]-1H-benziMidazole
CAS:88546-55-8
MF:C17H19N3O4S
MW:361.42
EINECS:
Product Categories:Various Metabolites and Impurities;Intermediates & Fine Chemicals;Metabolites;Pharmaceuticals;Acid pump inhibitors;Isotopically Labeled Pharmaceutical Reference Standard
Mol File:88546-55-8.mol
OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS) Structure
OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS) Chemical Properties
Melting point 80-82°C
Boiling point 599.3±60.0 °C(Predicted)
density 1.331±0.06 g/cm3(Predicted)
storage temp. Inert atmosphere,2-8°C
solubility ≥40.6 mg/mL in DMSO,≥19.9 mg/mL in EtOH,insoluble in H2O
pka7.97±0.10(Predicted)
form Solid
color White to off-white
BRN 8347309
Major Applicationpharmaceutical (small molecule)
InChI1S/C17H19N3O4S/c1-10-8-18-15(11(2)16(10)24-4)9-25(21,22)17-19-13-6-5-12(23-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20)
InChIKeyIXEQEYRTSRFZEO-UHFFFAOYSA-N
SMILESO=S(C1=NC2=CC(OC)=CC=C2N1)(CC3=NC=C(C)C(OC)=C3C)=O
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 2
HS Code 29333990
Storage Class11 - Combustible Solids
Hazard ClassificationsAcute Tox. 4 Oral
Aquatic Chronic 2
MSDS Information
OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS) Usage And Synthesis
DescriptionOmeprazole sulfone is the major metabolite of the gastric proton pump inhibitor, omeprazole . It is produced by cytochrome P450 (CYP)3A4 sulfoxidation of esomeprazole and is found in plasma. Omeprazole sulfone has been shown to act as a reversible direct-acting and metabolism-dependent inhibitor of CYP2C19 in pooled human liver microsomes (IC50 = 18 μM).
Chemical PropertiesLight Yellow Solid
UsesA metabolite of Omeprazole.
DefinitionChEBI: Omeprazole sulfone is a sulfoxide and a member of benzimidazoles.
in vitroomeprazole sulfone has been shown to act as a reversible direct-acting and metabolism-dependent inhibitor of cyp2c19 in pooled human liver microsomes with an ic50 of 18 μm [1].
in vivothree hours after intake of 20 mg omeprazole only, the geometric mean plasma concentration of omeprazole sulfone were 106 nmol/l in 22 samples from subjects known to be extensive cyp2c19 metabolizers (em) and 672 nmol/l in the five subjects known to be poor cyp2c19 metabolizers (pm). the mean log10(omeprazole/omeprazole sulfone) ratio was 0.18 [4].
references[1] nebert d w, russell d w. clinical importance of the cytochromes p450[j]. the lancet, 2002, 360(9340): 1155-1162.
[2] bel a, andersson t b, antonsson m, et al. stereoselective metabolism of omeprazole by human cytochrome p450 enzymes[j]. drug metabolism and disposition, 2000, 28(8): 966-972.
[3] nebert d w, russell d w. clinical importance of the cytochromes p450[j]. the lancet, 2002, 360(9340): 1155-1162.
[4] bttiger y. use of omeprazole sulfone in a single plasma sample as a probe for cyp3a4[j]. european journal of clinical pharmacology, 2006, 62(8): 621-625.
OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS) Preparation Products And Raw materials
Tag:OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS)(88546-55-8) Related Product Information
5-METHOXY-2-[(3,5-DIMETHYL-2-PYRIDINYL)-METHYLSULFINYL]-BENZIMIDAZOLE 8-Methoxy-1,3-dimethyl-12-thioxo-pyrido[123,4]imidazo[1,2-a]benzimidazol-2- (12H)-one 5-METHOXY-2-[((4-METHOXY-3,5-DIMETHYL-1-OXIDO-2-PYRIDINYL)METHYL)SULFINYL]-BENZIMIDAZOLE 4-Hydroxy Omeprazole Sulfide 2-[[(3,5-DiMethyl-2-pyridinyl)Methyl]thio]-6-Methoxy-1H-benziMidazole Ufiprazole (S)-4-Desmethoxy-4-chloro Omeprazole Omeprazole Ondansetron EP Impurity H ammonium 1-(5-methoxy-1H-benzo[d]imidazol-2-yl)-3,5-dimethyl-4-oxo-1,4-dihydropyridine-2-carboxylate 4-Hydroxy Omeprazole omeprazole acid 2-[(5-CARBOXY-4-METHOXY-3-METHYLPYRID-2-YL)-METHYLSULFO]-5-METHOXYBENZIMIDAZOLE 2-MERCAPTO-5-METHOXYBENZIMIDAZOLE Omeprazole EP Impurity G Omeprazole Sulfone N-Oxide OMEPRAZOLE IMP. C (EP): 5-METHOXY-2-[[(4-METHOXY-3,5-DIMETHYLPYRIDIN-2-YL)METHYL]SULPHANYL]-1H-BENZIMIDAZOLE (UFIPRAZOLE) MM STANDARD Omeprazole Impurity (2-[[(5-hydroxy-1H-benzimidazol-2-yl)sulfinyl]methyl]-3,5-dimethy-l-4(1H)-pyridone) Omeprazole Related Compound A
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