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TargetMol
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| Products Intro: |
Product Name:Fluphenazine hydrochloride
CAS:1254-47-3
Package:10mg;50mg
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| Company Name: |
Carbosynth
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| Tel: |
+86 512 6260 5585 |
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sales@carbosynth.com |
| Products Intro: |
Product Name:Fluphenazine hydrochloride
CAS:1254-47-3
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| | Fluphenazine hydrochloride Basic information |
| | Fluphenazine hydrochloride Chemical Properties |
| | Fluphenazine hydrochloride Usage And Synthesis |
| Uses | Fluphenazine hydrochloride is a potent, orally active phenothiazine-based dopamine receptor antagonist. Fluphenazine hydrochloride blocks neuronal voltage-gated sodium channels. Fluphenazine hydrochloride acts primarily through antagonism of postsynaptic dopamine-2 receptors in mesolimbic, nigrostriatal, and tuberoinfundibular neural pathways. Fluphenazine hydrochloride can antagonize Methylphenidate-induced stereotyped gnawing and inhibit climbing behaviour in mice. Fluphenazine hydrochloride can be used for researching psychosis and painful peripheral neuropathy associated with diabetes and has potential to inhibit SARS-CoV-2[1][2][3][4][6]. | | in vivo | Fluphenazine (1 mg/kg; IG, treated from day 6 to day 15 of gestation) hydrochloride causes malformations in pregnant mice[5].
Fluphenazine (0.125-1 mg/kg; IP, single dosage) antagonizes hydrochloride Methylphenidate-induced stereotyped gnawing; inhibits significantly climbing behaviour[6]. | Animal Model: | Mature female Swiss-Webster mice[5] | | Dosage: | 1 mg/kg | | Administration: | IG, treated from day 6 to day 15 of gestation | | Result: | Significantly reduced fetal weight and length, increased the incidence of incomplete ossification of sternebrae and skull bones.
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| Animal Model: | Mice (injected with 60 mg/kg Methylphenidate)[6] | | Dosage: | 0.125, 0.25, 0.5, and 1 mg/kg | | Administration: | IP, single dosage | | Result: | Antagonized Methylphenidate-induced stereotyped gnawing; inhibited significantly climbing behaviour in mice at 0.0625-0.5 mg/kg, and at the dose of 1 mg/kg abolished this effect completely.
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| | References | [1] Zhou X, et al. The neuroleptic drug, fluphenazine, blocks neuronal voltage-gated sodium channels. Brain Res. 2006;1106(1):72-81. DOI:10.1016/j.brainres.2006.05.076
[2] Nazeam J, et al. Based on Principles and Insights of COVID-19 Epidemiology, Genome Sequencing, and Pathogenesis: Retrospective Analysis of Sinigrin and ProlixinRX (Fluphenazine) Provides Off-Label Drug Candidates. SLAS Discov. 2020 Dec;25(10):1123-1140. DOI:10.1177/2472555220950236
[3] Siragusa S, Bistas KG, Saadabadi A. Fluphenazine. 2022 May 8. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan. PMID:29083807
[4] Davis JL, et al. Peripheral diabetic neuropathy treated with amitriptyline and fluphenazine. JAMA. 1977 Nov 21;238(21):2291-2. PMID:29083807
[5] Abdel-Hamid HA, et al. Teratogenic effect of diphenylhydantoin and/or fluphenazine in mice. J Appl Toxicol. 1996 May-Jun;16(3):221-5. DOI:10.1002/(SICI)1099-1263(199605)16:33.0.CO;2-Q
[6] Langwiński R, Niedzielski J. Narcotic analgesics and stereotyped behaviour in mice. Naunyn Schmiedebergs Arch Pharmacol. 1980 Jul;312(3):225-7. DOI:10.1007/BF00499150 |
| | Fluphenazine hydrochloride Preparation Products And Raw materials |
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