MAC glucuronide α-hydroxy lactone-linked SN-38

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MAC glucuronide α-hydroxy lactone-linked SN-38 Basic information
Product Name:MAC glucuronide α-hydroxy lactone-linked SN-38
Synonyms:MAC glucuronide α-hydroxy lactone-linked SN-38;MAC glucuronide α-hydroxy lactone-linked SN-38
CAS:2246380-70-9
MF:C50H54N6O20S
MW:1091.06
EINECS:
Product Categories:ADC LINKER
Mol File:2246380-70-9.mol
MAC glucuronide α-hydroxy lactone-linked SN-38 Structure
MAC glucuronide α-hydroxy lactone-linked SN-38 Chemical Properties
Boiling point 1399.8±65.0 °C(Predicted)
density 1.63±0.1 g/cm3(Predicted)
pka2.77±0.70(Predicted)
form Solid
color Light yellow to green yellow
Safety Information
MSDS Information
MAC glucuronide α-hydroxy lactone-linked SN-38 Usage And Synthesis
UsesMAC glucuronide α-hydroxy lactone-linked SN-38 (Topoisomerase I inhibitor) is a stabilized lactone MAC glucuronide α-hydroxy lactone-linked SN-38 agent linker. MAC glucuronide α-hydroxy lactone-linked SN-38 is cytotoxic across L540cy cells and Ramos cells with IC50 values of 99 and 105 ng/mL, respectively[1].
IC 50Camptothecins
References[1] Lau UY, et al. Lactone Stabilization is Not a Necessary Feature for Antibody Conjugates of Camptothecins. Mol Pharm. 2018 Sep 4;15(9):4063-4072. DOI:10.1021/acs.molpharmaceut.8b00477
MAC glucuronide α-hydroxy lactone-linked SN-38 Preparation Products And Raw materials
Tag:MAC glucuronide α-hydroxy lactone-linked SN-38(2246380-70-9) Related Product Information
MAC glucuronide linker-2 MAC glucuronide linker-1 4-ForMyl-2-nitrophenyl β-D-Glucopyranosiduronic Acid Methyl Ester 2,3,4-Triacetate (25,3R,45,55,65)-2-(4-(hydroxymethyl)-2-nitrophenoxy)-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate β-D-Glucopyranosiduronic acid, 2-formyl-4-nitrophenyl, methyl ester, 2,3,4-triacetate β-D-Glucopyranosiduronic acid, 2-[[3-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-1-oxopropyl]amino]-4-(hydroxymethyl)phenyl, methyl ester, 2,3,4-triacetate