| Company Name: |
Hubei Ipodix Biotechnology Co.,Ltd.
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| Tel: |
18007124176 19384116026 |
| Email: |
2706668885@qq.com |
| Products Intro: |
Product Name:AQP5 antibody
Purity:99% Package:50ul/RMB 1280;100ul/RMB 2180
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| Company Name: |
Shanghai Qierqi Biotech Co., Ltd.
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| Tel: |
027-19371278702 18008634902 |
| Email: |
ruihening88@163.com |
| Products Intro: |
Product Name:Rabbit Polyclonal AQP5 Antibody
Package:20μl;50μl;100μl
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| Company Name: |
NSJ Bioreagents
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| Tel: |
858.663.9055 8586639055 |
| Email: |
NSJBioname@qq.com |
| Products Intro: |
Product Name:AQP5 Antibody
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| Company Name: |
Enzo Biochem Inc
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| Tel: |
Enzo Biochem Inc. 13797054060 |
| Email: |
Enzoname@qq.com |
| Products Intro: |
Product Name:AQP5 Antibody
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| Product Name: | AQP5 Antibody | | Synonyms: | AQP5 Antibody;Rabbit Polyclonal AQP5 Antibody | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![AQP5 Antibody Structure]() |
| | AQP5 Antibody Chemical Properties |
| | AQP5 Antibody Usage And Synthesis |
| Source | Rabbit | | Reactivity | Human;Mouse;Rat | | Background | Aquaporin 5 is a plasma membrane water channel whose overexpression in human cancers, such as breast, pancreatic, and colon cancers, has been associated with poor prognosis and metastasis. In colorectal cancer cells, AQP5 has been shown to regulate migration and invasion, as well as expression of epithelial-mesenchymal transition factors. Knockdown of AQP5 inhibits the Wnt/β-Catenin pathway. Localization of AQP5 is altered in gastric cancer, and AQP5 is a marker for pyloric stem cells. In hepatocellular carcinoma, downregulation of AQP5 inhibits metastasis and EMT through inactivation of the NF-κB signaling pathway, and therefore, AQP5 is a potential therapeutic target for HCC. Phosphorylation of AQP5 at Ser156, possibly by PKA, activates the Ras signaling pathway in NIH/3T3 cells. AQP5 alters cell shape and actin dynamics without inducing EMT in normal epithelial Madin-Darby canine kidney cells, and this effect likely requires phosphorylation of AQP5 at Ser156. | | References | [1] Wang, W. et al. (2018) Cytotechnology 70, 615-624.
[2] Tan, S.H. et al. (2020) Nature 578, 437-443.
[3] He, Z. et al. (2017) Biochem Biophys Res Commun 490, 343-348.
[4] Woo, J. et al. (2008) Biochem Biophys Res Commun 367, 291-8.
[5] Jensen, H.H. et al. (2018) Am J Physiol Cell Physiol 314, C654-C661. |
| | AQP5 Antibody Preparation Products And Raw materials |
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