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| Product Name: | CHGA antibody | | Synonyms: | CHGA antibody;Rabbit Polyclonal CHGA Antibody | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![CHGA antibody Structure]() |
| | CHGA antibody Chemical Properties |
| | CHGA antibody Usage And Synthesis |
| Source | Rabbit | | Applications | CHGA antibody has been tested by ELISA, Western blot and immunohistochemistry analysis to assure specificity and reactivity. Recommended dilution range for Western blot is 1:500 ~ 1:1,000 and immunohistochemistry analysis is 1:100~200. Recommended starti | | Reactivity | Human | | Immunogen | Anti-human CHGA mAb is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human CHGA amino acids 19-131 purified from E. coli. | | Background | Chromgranin-A is part of the neuroendocrine secretory protein family. CHGA is located in secretory vesicles of neurons and endocrine cells. Chromgranin-A is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Other peptides, including chromostatin, beta-granin, WE-14 and GE-25, are also derived from the full-length protein. Chromgranin-A has numerous biological activities on some tissues and organs and exerts a large spectrum of homeostatic actions, including antifungal and antimicrobial effect, modulation of cell adhesion, and inhibition of parathyroid hormone secretion. | | References | [1] Machado, J.D. et al. (2010) Cell Mol Neurobiol 30, 1181-7.
[2] Dominguez, N. et al. (2018) J Neurochem 144, 241-54.
[3] Weisbrod, A.B. et al. (2013) Horm Cancer 4, 165-75.
[4] Annaratone, L. et al. (2014) Endocr Pathol 25, 219-28.
[5] Ardill, J.E. and Erikkson, B. (2003) Endocr Relat Cancer 10, 459-62.
[6] Welin, S. et al. (2009) Neuroendocrinology 89, 302-7. |
| | CHGA antibody Preparation Products And Raw materials |
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