N- [1- [(1R, 3S, 4S, 6R, 7S) - 4- [[Bis(4- Methoxyphenyl) - Phenylmethoxy] Methyl] - 7- [2- Cyanoeth

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N- [1- [(1R, 3S, 4S, 6R, 7S) - 4- [[Bis(4- Methoxyphenyl) - Phenylmethoxy] Methyl] - 7- [2- Cyanoeth Basic information
Product Name:N- [1- [(1R, 3S, 4S, 6R, 7S) - 4- [[Bis(4- Methoxyphenyl) - Phenylmethoxy] Methyl] - 7- [2- Cyanoeth
Synonyms:N- [1- [(1R, 3S, 4S, 6R, 7S) - 4- [[Bis(4- Methoxyphenyl) - Phenylmethoxy] Methyl] - 7- [2- Cyanoeth;Benzamide, N-[1-[2,5-anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-6-deoxy-α-L-mannofuranosyl]-1,2-dihydro-5-methyl-2-oxo-4-pyrimidinyl]-;5'-O-DMTr-cEt-BNA-N-Bz-Me-Cytidine-CEP;5'-ODMT cEt N-Bz 5-Me C Phosphoramidite;CET-5-Me-C(Bz) Phosphoramidite;5'-ODMTcEtN-Bzm5CPhosphoramiditeAmidite;S-cEt-5Me-C(Bz)-CE-Phosphoramidite;N6-Bz-C-(S)-cEt-Phosphoramidite
CAS:1197033-17-2
MF:C49H56N5O9P
MW:889.97
EINECS:
Product Categories:Amidite
Mol File:1197033-17-2.mol
N- [1- [(1R, 3S, 4S, 6R, 7S) - 4- [[Bis(4- Methoxyphenyl) - Phenylmethoxy] Methyl] - 7- [2- Cyanoeth Structure
N- [1- [(1R, 3S, 4S, 6R, 7S) - 4- [[Bis(4- Methoxyphenyl) - Phenylmethoxy] Methyl] - 7- [2- Cyanoeth Chemical Properties
pka8.60±0.40(Predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
N- [1- [(1R, 3S, 4S, 6R, 7S) - 4- [[Bis(4- Methoxyphenyl) - Phenylmethoxy] Methyl] - 7- [2- Cyanoeth Usage And Synthesis
Uses5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite is a potent nucleic acid analog. 5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite blongs to modified antisense oligonucleotide. 5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite allows the formation of a specific conformation of the furanose ring of the oligonucleotide through the introduction of a cEt modification, enhancing the ability to hybridize to complementary RNA. 5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite is mainly used in the research of regulation of gene expression related to metabolic diseases, cardiovascular diseases, cancers and the development of antisense compounds[1][2].
References[1] Yu J, et al. Synthesis and antisense properties of 2'-O-(2S-methoxypropyl)-RNA-modified gapmer antisense oligonucleotides. ChemMedChem. 2014 Sep;9(9):2040-4. DOI:10.1002/cmdc.201402099
[2] Seth P P, et al. Synthesis and biophysical evaluation of 2′, 4′-constrained 2′ O-methoxyethyl and 2′, 4′-constrained 2′ O-ethyl nucleic acid analogues. The Journal of organic chemistry, 2010, 75(5): 1569-1581.
N- [1- [(1R, 3S, 4S, 6R, 7S) - 4- [[Bis(4- Methoxyphenyl) - Phenylmethoxy] Methyl] - 7- [2- Cyanoeth Preparation Products And Raw materials
Tag:N- [1- [(1R, 3S, 4S, 6R, 7S) - 4- [[Bis(4- Methoxyphenyl) - Phenylmethoxy] Methyl] - 7- [2- Cyanoeth(1197033-17-2) Related Product Information
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