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| | 7-Ketocholesteryl-9-carboxynonanoate Basic information |
| | 7-Ketocholesteryl-9-carboxynonanoate Chemical Properties |
| Boiling point | 662.6±55.0 °C(Predicted) | | density | 1.07±0.1 g/cm3(Predicted) | | solubility | DMSO: Slightly soluble: 0.1-1 mg/ml | | pka | 4.77±0.10(Predicted) |
| | 7-Ketocholesteryl-9-carboxynonanoate Usage And Synthesis |
| Uses | oxLig-1 (7-Ketocholesteryl-9-carboxynonanoate) is the lipid moiety of oxidized low-density lipoprotein (oxLDL) and is a key ligand for β-glycoprotein I (β(2)-GPI). oxLig-1 causes nuclear translocation by activating the NF-κB pathway. oxLig-1 can be used in the study of atherosclerosis (AS)[1]. | | References | [1] Huang Z, et al. 7-ketocholesteryl-9-carboxynonanoate induced nuclear factor-kappa B activation in J774A.1 macrophages. Life Sci. 2010 Nov 20;87(19-22):651-7. DOI:10.1016/j.lfs.2010.09.028
[2] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[3] YAN CHI . 7-Ketocholesteryl-9-carboxynonanoate enhances ATP binding cassette transporter A1 expression mediated by PPARγ in THP-1 macrophages[J]. Atherosclerosis, 2014, 234 2: Pages 461-468. DOI: 10.1016/j.atherosclerosis.2014.01.052
[4] CHANGZHEN FU, QINGPING LIU* Molecular Drug Simulation and Experimental Validation of the CD36 Receptor Competitively Binding to Long-Chain Fatty Acids by 7-Ketocholesteryl-9-carboxynonanoate[J]. ACS Omega, 2023, 8 31: 28277-28289. DOI: 10.1021/acsomega.3c02082
[5] DANIEL LOPEZ. IgG autoantibodies against beta2-glycoprotein I complexed with a lipid ligand derived from oxidized low-density lipoprotein are associated with arterial thrombosis in antiphospholipid syndrome.[J]. Clinical & Developmental Immunology, 2003, 10 2-4: 203-211. DOI: 10.1080/10446670310001642113 |
| | 7-Ketocholesteryl-9-carboxynonanoate Preparation Products And Raw materials |
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