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| | Cleaved Gasdermin D (Asp275) (E7H9G) Rabbit mAb Chemical Properties |
| | Cleaved Gasdermin D (Asp275) (E7H9G) Rabbit mAb Usage And Synthesis |
| Source | Rabbit | | Reactivity | Human | | Background | Gasdermin D, a member of the gasdermin family that includes GSDMA, GSDMB, and GSDMC, has been reported to have a critical role as a downstream effector of pyroptosis. Pyroptosis is a lytic type of cell death triggered by inflammasomes, multiprotein complexes assembled in response to pathogen-associated molecular patterns or danger-associated molecular patterns that result in the activation of caspase-1 and subsequent cleavage of pro-inflammatory cytokines IL-1β and IL-18. Gasdermin D was identified by two independent groups as a substrate of inflammatory caspases, caspase-1 and caspase-11/4/5, producing two fragments: GSDMD-N and GSDMD-C. Cleavage results in release of an intramolecular inhibitory interaction between the N- and C-terminal domains, allowing the N-terminal fragment GSDMD-N to initiate pyroptosis through the formation of pores on the plasma membrane. | | References | [1] Kayagaki, N. et al. (2015) Nature 526, 666-71.
[2] Shi, J. et al. (2015) Nature 526, 660-5.
[3] Broz, P. and Dixit, V.M. (2016) Nat Rev Immunol 16, 407-20.
[4] Aglietti, R.A. et al. (2016) Proc Natl Acad Sci U S A 113, 7858-63.
[5] Ding, J. et al. (2016) Nature 535, 111-6.
[6] Liu, X. et al. (2016) Nature 535, 153-8.
[7] Sborgi, L. et al. (2016) EMBO J 35, 1766-78. |
| | Cleaved Gasdermin D (Asp275) (E7H9G) Rabbit mAb Preparation Products And Raw materials |
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