| Company Name: |
J & K SCIENTIFIC LTD.
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| Tel: |
18210857532; 18210857532 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:Flurbiprofen-d3
CAS:1185133-81-6
Package:50Mg,5Mg
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| Company Name: |
Daicel Chiral Technologies (China)CO.,LTD
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| Tel: |
021-50460086-9 15921403865 |
| Email: |
han_yajun@dctc.daicel.com |
| Products Intro: |
Product Name:Flurbiprofen - D3
CAS:1185133-81-6
Purity:95%HPLC Package:10MG;25MG;50MG;100MG Remarks:DCTI-A-226
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| Company Name: |
Quality Control Solutions Ltd.
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| Tel: |
0755-66853366 13670046396 |
| Email: |
orders@qcsrm.com |
| Products Intro: |
Product Name:Flurbiprofen-d3
CAS:1185133-81-6
Purity:95% HPLC Package:10mg;25mg;50mg;100mg
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| | FLURBIPROFEN-D3 Basic information |
| | FLURBIPROFEN-D3 Chemical Properties |
| Melting point | 108-110°C | | storage temp. | -20°C Freezer | | solubility | DMF: 25 mg/ml,DMSO: 10 mg/ml,Ethanol: 25 mg/ml,PBS (pH 7.2): 0.9 mg/ml | | form | A solid | | color | White to off-white |
| | FLURBIPROFEN-D3 Usage And Synthesis |
| Description | Flurbiprofen-d3 is intended for use as an internal standard for the quantification of flurbiprofen (Item Nos. 70250 | 10004207 | 70255) by GC- or LC-MS. Flurbiprofen is a non-selective COX inhibitor (IC50s = 0.04 and 0.51 μM for COX-1 and COX-2, respectively). In vivo, flurbiprofen (0.3-4.8 mg/kg, p.o.) reduces carrageenan-induced hind paw edema and yeast-induced fever in rats. Flurbiprofen reduces plasma fibrinogen levels and arthritic score in a rat model of adjuvant-induced arthritis. It also reduces tumor weight and prostaglandin production and increases survival in a WHT-NC mouse xenograft model when administered at a dose of 5 mg/kg. Formulations containing flurbiprofen have been used to manage pain and inflammation associated with arthritis. | | Chemical Properties | White Solid | | Uses | An Isotopically labeled analog of Flurbiprofe | | Uses | An isotopically labelled analog of Flurbiprofen (F598700). | | References | [1] E M GLENN. The pharmacology of 2-(2-fluoro-4-biphenylyl)propionic acid (flurbiprofen). A potent non-steroidal anti-inflammatory drug.[J]. Agents and Actions, 1973, 3 4: 210-216. DOI: 10.1007/bf01968544
[2] A BENNETT. Tumour growth and response to treatment: beneficial effect of the prostaglandin synthesis inhibitor flurbiprofen [proceedings].[J]. British Journal of Pharmacology, 1978, 63 2: 356P-357P.
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| | FLURBIPROFEN-D3 Preparation Products And Raw materials |
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