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| | H-AVPIAQK-OH Basic information |
| Product Name: | H-AVPIAQK-OH | | Synonyms: | H-AVPIAQK-OH;H-ALA-VAL-PRO-ILE-ALA-GLN-LYS-OH;AVPIAQK;SMAC-N7 PEPTIDE;SMAC N7 PROTEIN;SMAC PROTEIN (1-7) (HUMAN, MOUSE);Mitochondrial Diablo HoMolog (1-7) (huMan, Mouse), Second Mitochondria-derived Activator of Caspase (1-7) (huMan, Mouse), SMac Protein (1-7) (huMan, Mouse);L-Lysine, L-alanyl-L-valyl-L-prolyl-L-isoleucyl-L-alanyl-L-glutaminyl- | | CAS: | 401913-57-3 | | MF: | C33H59N9O9 | | MW: | 725.88 | | EINECS: | | | Product Categories: | peptide | | Mol File: | 401913-57-3.mol |  |
| | H-AVPIAQK-OH Chemical Properties |
| Boiling point | 1147.315±65.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.223±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | storage temp. | -20°C | | form | lyophilized solid | | pka | 3.274±0.10(predicted) | | color | white | | Water Solubility | water: 1mg/mL
DMSO: 5mg/mL | | Sequence | Ala-Val-Pro-Ile-Ala-Gln-Lys |
| | H-AVPIAQK-OH Usage And Synthesis |
| Uses | Smac-N7 peptide, the seven N-terminal amino acid of the mitochondrial protein Smac (second mitochondria-derived activator of caspase), cannot pass through the cell membrane[1]. | | Biological Activity | Cell permeable: no', 'Kd ~800 nM in binding to the BIR2 and BIR3 (baculovirus IAP repeat) domains of XIAP (X-linked inhibitor of apoptosis proteins)', 'Primary Target
Promotes the catalytic activity of caspase-9 in the presence of XIAP', 'Product does not compete with ATP.', 'Reversible: no | | References | [1] S Heckl, et al. A novel polyarginine containing Smac peptide conjugate that mediates cell death in tumor and healthy cells. Med Chem. 2008 Jul;4(4):348-54. DOI:10.2174/157340608784872217 |
| | H-AVPIAQK-OH Preparation Products And Raw materials |
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