2-PIPERAZINE-4-AMINO-6,7-DIMETHOXY QUINOLINE HYDROCHLORIDE manufacturers
- 2-PADQZ hydrochloride
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- $70.00 / 1mg
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2026-05-11
- CAS:84050-22-6
- Min. Order:
- Purity: 99.61%
- Supply Ability: 10g
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| | 2-PIPERAZINE-4-AMINO-6,7-DIMETHOXY QUINOLINE HYDROCHLORIDE Basic information |
| Product Name: | 2-PIPERAZINE-4-AMINO-6,7-DIMETHOXY QUINOLINE HYDROCHLORIDE | | Synonyms: | 2-PIPERAZINYL-4-AMINO-6,7-DIMETHOXYQUINAZOLINEHCL;4-Amino-2-piperazin-6,7-dimethoxyquinolinehydrochloride;2-Piperazinyl-6,7-dimethoxyquinazolin-4-amine hydrochlorode;Piperazine amino dimethoxy quinaoline hydrochloride;2-Piperazine-4-amino-6,7-dimethoxy quinazoline HCl;2-PIPERAZINE-4-AMINO-6,7-DIMETHOXY QUINOLINE HYDROCHLORIDE;2-Piperazinyl-4-amino-6,7-dimethoxyquinazoline Hydrochloride;2-PIPERAZINE-4-AMINO-6,7-DIMETHOXY QUINAOLINE HYDROCHLORIDE | | CAS: | 84050-22-6 | | MF: | C14H20ClN5O2 | | MW: | 325.79 | | EINECS: | | | Product Categories: | | | Mol File: | 84050-22-6.mol |  |
| | 2-PIPERAZINE-4-AMINO-6,7-DIMETHOXY QUINOLINE HYDROCHLORIDE Chemical Properties |
| | 2-PIPERAZINE-4-AMINO-6,7-DIMETHOXY QUINOLINE HYDROCHLORIDE Usage And Synthesis |
| Uses | DPQ hydrochloride is a blood-brain barrier permeable and selective PARP-1 inhibitor that blocks PARP-1-mediated DNA damage repair and NAD+/ATP consumption, thereby inhibiting excessive inflammatory responses. DPQ hydrochloride inhibits NF-κB pathway activation, reduces the expression of pro-inflammatory factors (such as TNF-α, IL-6) and oxidative stress. DPQ hydrochloride can be used in inflammation-related studies of acute lung injury, myocardial infarction, and neurodegenerative diseases[1][2][3]. | | in vivo | DPQ hydrochloride (10 mg/kg; intraperitoneal injection; single dose; 6 h) significantly attenuates lung inflammation, neutrophil infiltration, and vascular leakage in LPS-induced acute lung injury model of C57BL/6 mice, inhibiting NF-κB pathway activation[2].
DPQ hydrochloride (10 mg/kg; intraperitoneal injection; single dose; 4 weeks) improves cardiac function and reduced apoptosis and oxidative stress in myocardial infarction model of Wistar rats[3].
| Animal Model: | LPS-Induced Acute Lung Injury Model in C57BL/6 mice (male, 8-10 weeks old)[2] | | Dosage: | 10 μg/kg (dissolved in 0.01% DMSO (PBS) | | Administration: | Intraperitoneal injection, 30 min after LPS chanllenge (7.5 mg/kg; ip; single dose)
| | Result: | Reduced neutrophil infiltration (50% decrease), MPO activity (40% decrease), and pro-inflammatory cytokines (TNF-α, IL-1β, IL-6) in lungs. Restored vascular permeability (Evans blue extravasation reduced by 35%), and inhibited apoptotic cell death (TUNEL-positive cells decreased by 45%).
Suppressed NF-κB activation with reduced IkB-α degradation and p65 phosphorylation.
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| Animal Model: | Wistar rats (male, 4 months old) + MI via coronary artery ligation[3] | | Dosage: | 10 mg/kg (dissolved in DMSO) | | Administration: | Intraperitoneal injection, single dose immediately after MI induction | | Result: | Improved cardiac function (FS increased by 25%, EDD/ESD reduced by 15%), decreased apoptotic cardiomyocytes (TUNEL-positive cells reduced by 40%), and suppressed cleaved caspase-3 and PARP1 expression. Oxidative stress markers (O2-, nitrotyrosine) were reduced by 30-40% in infarcted myocardium.
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| | IC 50 | PARP-1 | | References | [1] Meli E, et al. Differential role of poly (ADP-ribose) polymerase-1in apoptotic and necrotic neuronal death induced by mild or intense NMDA exposure in vitro. Mol Cell Neurosci. 2004;25 (1) :172-180. DOI:10.1016/j.mcn.2003.09.016
[2] Wang G, et al. PARP-1 inhibitor, DPQ, attenuates LPS-induced acute lung injury through inhibiting NF-κB-mediated inflammatory response. PLoS One. 2013 Nov 21;8 (11) :e79757. DOI:10.1371/journal.pone.0079757
[3] Wang J, et al. Inhibition of poly (ADP-ribose) polymerase and inducible nitric oxide synthase protects against ischemic myocardial damage by reduction of apoptosis. Mol Med Rep. 2015 Mar;11 (3) :1768-76. DOI:10.3892/mmr.2014.2977 |
| | 2-PIPERAZINE-4-AMINO-6,7-DIMETHOXY QUINOLINE HYDROCHLORIDE Preparation Products And Raw materials |
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