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| | MCA-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys(Dnp)-OH Basic information |
| Product Name: | MCA-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys(Dnp)-OH | | Synonyms: | MCA-(ALA7,LYS(DNP)9)-BRADYKININ;L-Lysine, N2-[2-(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-arginyl-L-prolyl-L-prolylglycyl-L-phenylalanyl-L-seryl-L-alanyl-L-phenylalanyl-N6-(2,4-dinitrophenyl)-;N2-[2-(7-Methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-arginyl-L-prolyl-L-prolylglycyl-L-phenylalanyl-L-seryl-L-alanyl-L-phenylalanyl-N6-(2,4-dinitrophenyl)-L-lysine;(7-methoxycoumarin-4-yl)acetyl-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys-(2,4-dinitrophenyl);7-Methoxycoumarin-4-acetyl [Ala7-(2,4-Dinitrophenyl)Lys9]-Bradykinin;Matrix metalloproteinases MMP FRET Substrate V, bradykinin Mca- (Ala?, Lys(Dnp)?;Mca-(Ala7,Lys(Dnp)9)-Bradykinin trifluoroacetate salt;MCA-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys(Dnp)-OH | | CAS: | 323577-36-2 | | MF: | C66H81N15O19 | | MW: | 1388.44 | | EINECS: | | | Product Categories: | | | Mol File: | 323577-36-2.mol |  |
| | MCA-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys(Dnp)-OH Chemical Properties |
| density | 1.48±0.1 g/cm3(Predicted) | | storage temp. | -15°C | | pka | 3.38±0.10(Predicted) | | form | Solid | | color | Light yellow to yellow | | Appearance | White or Off-white Lyophilized Powder |
| | MCA-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys(Dnp)-OH Usage And Synthesis |
| Description | Mca-(Ala7,Lys(Dnp)9)-Bradykinin is a very sensitive internally quenched fluorescent substrate for endothelin-converting enzyme-1 (ECE-1), a membrane-bound zinc metallopeptidase related to neprilysin in amino acid sequence. It is used as a substrate for insulin-degrading enzymes (IDE) and ACE2. | | Uses | Mca-(ala7,lys(dnp)9)-bradykinin is a sensitive fluorogenic substrate for ECE-1 (endothelin-converting enzyme-1). The incorporation of a (7-methoxycoumarin-4-yl)acetyl (Mca) fluorescent group and a 2,4-dinitrophenyl (Dnp) quenching group has resulted in a large fluorescence increase upon substrate cleavage[1]. | | References | [1] Johnson GD, et al. Development of an internally quenched fluorescent substrate selective for endothelin-converting enzyme-1. Anal Biochem. 2000 Nov 1;286(1):112-8. DOI:10.1006/abio.2000.4772 | | Sequene | Mca-RPPGFSAFK(Dnp) |
| | MCA-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys(Dnp)-OH Preparation Products And Raw materials |
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