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| | Ethyl N-piperazinecarboxylate Basic information |
| Product Name: | Ethyl N-piperazinecarboxylate | | Synonyms: | Ethoxycarbonyl piperazine;Ethyl N-piperazinecartoxylate;1-Ethoxycarbonylpiperazine ,99%;Ethyl N-piperazinecarboxylate, 99% 25GR;1-Ethoxycarbonylpiperazine
1-Piperazinecarboxylic Acid Ethyl Ester;1-ETHOXYCARBONYL PIPERAZINE FOR SYNTHESI;N-Carboethoxypiperazine 1-Carboethoxy piperazine;1-Ethoxycarbonyl piperazine for synthesis | | CAS: | 120-43-4 | | MF: | C7H14N2O2 | | MW: | 158.2 | | EINECS: | 204-395-2 | | Product Categories: | Piperidines, Piperidones, Piperazines;PIPERIDINE;1 | | Mol File: | 120-43-4.mol |  |
| | Ethyl N-piperazinecarboxylate Chemical Properties |
| Hazard Codes | Xn,T | | Risk Statements | 22-36/37/38-20/21/22 | | Safety Statements | 23-24/25-37/39-26-36 | | RIDADR | UN 2810 6.1/PG 3 | | WGK Germany | 3 | | RTECS | TL1378000 | | Hazard Note | Toxic | | TSCA | TSCA listed | | HazardClass | 6.1(b) | | PackingGroup | III | | HS Code | 29335995 | | Storage Class | 10 - Combustible liquids |
| | Ethyl N-piperazinecarboxylate Usage And Synthesis |
| Chemical Properties | clear light yellow oily liquid | | Uses | Intermediate. | | Synthesis | Piperazine (2 g, 23.2 mmol) and deionized water (10 mL) were added to a reaction flask and stirred at 25 °C until completely dissolved, then cooled to 0 °C. A methanol solution (20 mL) of ethyl chloroformate (1.26 g, 11.6 mmol) was slowly added dropwise with stirring. After the dropwise addition was completed, the reaction system was warmed to 25 °C and stirring was continued for 4 hours. Upon completion of the reaction, saturated aqueous sodium chloride solution (30 mL) and dichloromethane (200 mL) were added to the reaction solution for extraction and separation. The organic layer was collected and dried with anhydrous sodium sulfate. The organic solvent was removed by distillation under reduced pressure, and the resulting crude product was purified by column chromatography (eluent: dichloromethane/methanol, 40:1, v/v/v/v) to give ethyl N-piperazinecarboxylate (0.62 g, 33.7% yield) as a white solid. | | References | [1] Patent: CN103664899, 2017, B. Location in patent: Paragraph 0465-0469
[2] Patent: CN103664925, 2018, B. Location in patent: Paragraph 0458; 0461; 0462
[3] Journal of the Chemical Society, 1929, p. 50
[4] Journal of Organic Chemistry, 1948, vol. 13, p. 134,138
[5] Chemische Berichte, 1933, vol. 66, p. 113,116 |
| | Ethyl N-piperazinecarboxylate Preparation Products And Raw materials |
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