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| | H-Arg-Arg-Ala(2-naphthyl)-Cys-Tyr-Arg-Lys-D-Lys-Pro-Tyr-Arg-Cit-Cys-Arg-OH Basic information |
| Product Name: | H-Arg-Arg-Ala(2-naphthyl)-Cys-Tyr-Arg-Lys-D-Lys-Pro-Tyr-Arg-Cit-Cys-Arg-OH | | Synonyms: | Polyphemusin II-Derived Peptide, T140;T140;POLYPHEMUSIN II-DERIVED PEPTIDE;L-Arginine, L-arginyl-L-arginyl-3-(2-naphthalenyl)-L-alanyl-L-cysteinyl-L-tyrosyl-L-arginyl-L-lysyl-D-lysyl-L-prolyl-L-tyrosyl-L-arginyl-N5-(aminocarbonyl)-L-ornithyl-L-cysteinyl-, cyclic (4→13)-disulfide;T140、Polyphemusin II-Derived Peptide;H-Arg-Arg-Ala(2-naphthyl)-Cys-Tyr-Arg-Lys-D-Lys-Pro-Tyr-Arg-Cit-Cys-Arg-OH | | CAS: | 229030-20-0 | | MF: | C90H141N33O18S2 | | MW: | 2037.42 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File |  |
| | H-Arg-Arg-Ala(2-naphthyl)-Cys-Tyr-Arg-Lys-D-Lys-Pro-Tyr-Arg-Cit-Cys-Arg-OH Chemical Properties |
| Sequence | Arg-Arg-2-Nal-Cys-Tyr-Arg-Lys-D-Lys-Pro-Tyr-Arg-Cit-Cys-Arg (Disulfide bridge:Cys4-Cys13) |
| | H-Arg-Arg-Ala(2-naphthyl)-Cys-Tyr-Arg-Lys-D-Lys-Pro-Tyr-Arg-Cit-Cys-Arg-OH Usage And Synthesis |
| Uses | Polyphemusin II-Derived Peptide (T140), a CXCR4 inhibitor, shows high inhibitory activity against HIV-1 entry and the inhibitory effect on the binding of an anti-CXCR4 monoclonal antibody (12G5) to CXCR4[1]. | | References | [1] H Tamamura, et al. A low-molecular-weight inhibitor against the chemokine receptor CXCR4: a strong anti-HIV peptide T140. Biochem Biophys Res Commun. 1998 Dec 30;253(3):877-82. DOI:10.1006/bbrc.1998.9871 |
| | H-Arg-Arg-Ala(2-naphthyl)-Cys-Tyr-Arg-Lys-D-Lys-Pro-Tyr-Arg-Cit-Cys-Arg-OH Preparation Products And Raw materials |
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