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| | 2-Fluoro-4-methoxyacetophenone Basic information |
| | 2-Fluoro-4-methoxyacetophenone Chemical Properties |
| Melting point | 52-54 °C(lit.) | | Boiling point | 80-85 °C (0.1 mmHg) | | density | 1.1410 (estimate) | | Fp | >230 °F | | storage temp. | Sealed in dry,Room Temperature | | form | Viscous Solution | | color | Clear colorless | | Water Solubility | Insoluble | | BRN | 3539992 | | CAS DataBase Reference | 74457-86-6(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36-37/39 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 29147000 |
| | 2-Fluoro-4-methoxyacetophenone Usage And Synthesis |
| Chemical Properties | white to light yellow crystal powder | | Uses | 2′-Fluoro-4′-methoxyacetophenone may be used in chemical synthesis. | | Preparation | Obtained by reaction of acetic anhydride with 3-fluoroanisole in the presence of aluminium chloride in carbon disulfide at r.t., then at 30–35° until no more hydrochloric acid is evolved. | | Synthesis | 3-Fluoro-4-methoxyacetophenone oxime ether (39.4 mg, 0.2 mmol) was dissolved in 2 mL of ether, 37% hydrochloric acid was added and the reaction was stirred for 30 h at room temperature. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction solution was neutralized with saturated sodium carbonate solution to pH 7, followed by extraction of the mixture with ether (10 mL × 3). The organic phases were combined, dried with anhydrous sodium sulfate, and concentrated under reduced pressure to remove the solvent. The crude product was purified by column chromatography (eluent ratio: petroleum ether/ethyl acetate = 20:1, v/v), and the eluent containing the target product was collected, and the solvent was removed by distillation under reduced pressure to afford 2-fluoro-4-methoxyacetophenone (26.5 mg, 79% yield). | | References | [1] Patent: CN103922904, 2016, B. Location in patent: Paragraph 0058; 0059; 0062 |
| | 2-Fluoro-4-methoxyacetophenone Preparation Products And Raw materials |
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