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| | 2-Nitro-N-hydroxyethyl aniline Basic information |
| Product Name: | 2-Nitro-N-hydroxyethyl aniline | | Synonyms: | 2-[(2-nitrophenyl)amino]-ethano;4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoro-2-iodo-1-undecanol;Ethanol,2-[(2-nitrophenyl)amino]-;N-(2-HYDROXYETHYL)-2-NITROANILINE;2-[(2-NITROPHENYL)AMINO]ETHANOL;2-NITRO-N-(HYDROXYETHYL)ANILINE;2-NITRO-N-(2-HYDROXYETHYL)ANILINE;hc-yelow 2 | | CAS: | 4926-55-0 | | MF: | C8H10N2O3 | | MW: | 182.18 | | EINECS: | 225-555-8 | | Product Categories: | Electronic Chemicals;Intermediates of Dyes and Pigments | | Mol File: | 4926-55-0.mol |  |
| | 2-Nitro-N-hydroxyethyl aniline Chemical Properties |
| Melting point | 71-73°C | | Boiling point | 376.6±22.0 °C(Predicted) | | density | 1.352±0.06 g/cm3(Predicted) | | vapor pressure | 0Pa at 20℃ | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | Chloroform (Slightly), Methanol (Slightly) | | form | Solid | | pka | 14.60±0.10(Predicted) | | color | Dark Orange to Red | | Water Solubility | 1.85g/L at 20℃ | | λmax | 441nm(NaOH aq.)(lit.) | | Cosmetics Ingredients Functions | HAIR DYEING | | Cosmetic Ingredient Review (CIR) | 2-Nitro-N-hydroxyethyl aniline (4926-55-0) | | InChI | InChI=1S/C8H10N2O3/c11-6-5-9-7-3-1-2-4-8(7)10(12)13/h1-4,9,11H,5-6H2 | | InChIKey | LFOUYKNCQNVIGI-UHFFFAOYSA-N | | SMILES | C(O)CNC1=CC=CC=C1[N+]([O-])=O | | LogP | 1.5 at 20℃ | | CAS DataBase Reference | 4926-55-0(CAS DataBase Reference) | | EPA Substance Registry System | Ethanol, 2-[(2-nitrophenyl)amino]- (4926-55-0) |
| Hazard Codes | Xi | | Hazard Note | Irritant | | TSCA | TSCA listed | | HS Code | 2922290090 |
| | 2-Nitro-N-hydroxyethyl aniline Usage And Synthesis |
| Chemical Properties | Orange crystal powder | | Uses | 2-(2-Nitroanilino)ethanol is used in the preparation of (phenylamino)quinoxalinone derivatives which has been identified as a new class of glycogen phosphorylase inhibitors. | | Flammability and Explosibility | Not classified | | Synthesis | In a 1L three-necked flask, 100 g of o-chloronitrobenzene, 450 g of hexane and 10 g of sodium fluoride were added sequentially and the temperature was raised to 80 °C. 60g of ethanolamine was slowly added dropwise, and the reaction temperature was maintained at 80°C for 20 hours. Sampling and analysis were carried out during the reaction, monitored by HPLC, and the reaction was terminated when the content of o-chloronitrobenzene was less than 3%. Upon completion of the reaction, decompression distillation was carried out to remove the solvent and the distillation temperature was controlled at 90 °C. Subsequently, methanol and water were added for crystallization, and after filtration, washing and drying, 103 g of red crystalline powder N-(2-nitrophenyl)ethanolamine was obtained, with a purity of 99.6% by HPLC. | | References | [1] Heterocycles, 1999, vol. 51, # 11, p. 2561 - 2573
[2] Journal of the American Chemical Society, 1939, vol. 61, p. 1321,1323,1324
[3] Helvetica Chimica Acta, 1936, vol. 19, p. 1029,1030, 1033
[4] Chemische Berichte, 1947, vol. 80, p. 263,270
[5] Patent: US2434564, 1943, |
| | 2-Nitro-N-hydroxyethyl aniline Preparation Products And Raw materials |
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