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| | 2-Bromo-4-chloro-1-fluorobenzene Basic information | | Application |
| | 2-Bromo-4-chloro-1-fluorobenzene Chemical Properties |
| Boiling point | 180 °C | | density | 1.719 | | refractive index | 1.554 | | Fp | 180°C | | storage temp. | Sealed in dry,Room Temperature | | form | clear liquid | | color | Colorless to Light yellow to Light orange | | InChI | InChI=1S/C6H3BrClF/c7-5-3-4(8)1-2-6(5)9/h1-3H | | InChIKey | YFFUYGSLQXVHMB-UHFFFAOYSA-N | | SMILES | C1(F)=CC=C(Cl)C=C1Br | | CAS DataBase Reference | 1996-30-1(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36/37/39-24/25 | | WGK Germany | 3 | | Hazard Note | Irritant | | HS Code | 29039990 | | Storage Class | 10 - Combustible liquids |
| | 2-Bromo-4-chloro-1-fluorobenzene Usage And Synthesis |
| Application | 3-Bromo-1-chloro-4-fluorobenzene is an organic intermediate that can be prepared from p-fluoronitrobenzene via a three-step reaction. Literature reports that it can be used to prepare 5-chloro-2-methoxybenzonitrile, which is mainly used in the pharmaceutical and pesticide industries. | | Description | 3-Bromo-1-chloro-4-fluorobenzene is an organic intermediate prepared from p-fluoronitrobenzene through a three-step reaction. Literature reports that it can be used to prepare 5-chloro-2-methoxybenzonitrile, which is mainly used in the pharmaceutical and pesticide industries. | | Chemical Properties | Colorless to light yellow liquid | | Synthesis | (1) Bromination: p-Fluoronitrobenzene reacts with N-bromosuccinimide in acetic acid at 15??C to yield 3-bromo-4-fluoronitrobenzene. (2) Reduction: 3-Bromo-4-fluoronitrobenzene is reduced with iron powder/ammonium chloride to give 3-bromo-4-fluoroaniline. (3) Diazotization-Sandmeyer: 3-Bromo-4-fluoroaniline is diazotized and then reacted with cuprous chloride to yield 3-bromo-1-chloro-4-fluorobenzene. |
| | 2-Bromo-4-chloro-1-fluorobenzene Preparation Products And Raw materials |
| Raw materials | 2-Bromo-4-chloroaniline-->1-bromo-5-chloro-2-fluoro-4-iodoBenzene-->1-Chloro-4-fluorobenzene | | Preparation Products | CarbaMic acid, N-[5-chloro-2-fluoro-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl]-, 1,1-diMethylethyl ester-->3-BROMO-5-CHLORO-2-FLUOROANILINE-->Methyl 3-bromo-5-chloro-2-fluorobenzoate-->CarbaMic acid, N-[(1S)-2-[[4-[3-[5-chloro-3-[[(1,1-diMethylethoxy)carbonyl]aMino]-2-fluorophenyl]-1-(1-Methylethyl)-1H-pyrazol-4-yl]-2-pyriMidinyl]aMino]-1-Methylethyl]-, Methyl ester |
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