|
|
| | Ethyl thiophene-3-carboxylate Basic information |
| Product Name: | Ethyl thiophene-3-carboxylate | | Synonyms: | ETHYL 3-THIOPHENEACETATE;ETHYL 3-THIENYLACETATE;ETHYL THIOPHENE-3-CARBOXYLATE;ETHYL THIOPHENE-3-ACETATE;7-[3,4-dihydroxy-5-(hydroxymethyl)-2-oxolanyl]-4-(prop-2-enylthio)-5-pyrrolo[2,3-d]pyrimidinecarbonitrile;RARECHEM AL BI 0549;ethyl 3-thenoate;Ethylthiophene-3-carboxylate,98% | | CAS: | 5751-80-4 | | MF: | C7H8O2S | | MW: | 156.2 | | EINECS: | 227-275-1 | | Product Categories: | | | Mol File: | 5751-80-4.mol |  |
| | Ethyl thiophene-3-carboxylate Chemical Properties |
| Boiling point | 97-98 °C (8 mmHg) | | density | 1.12 | | refractive index | 1.509-1.511 | | Fp | 103 °C | | storage temp. | Keep in dark place,Sealed in dry,2-8°C | | form | clear liquid | | color | Colorless to Light yellow to Light orange | | Water Solubility | Soluble in water. |
| Safety Statements | 24/25-23 | | HS Code | 29349990 |
| | Ethyl thiophene-3-carboxylate Usage And Synthesis |
| Chemical Properties | Colorless liquid | | Uses | Ethyl thiophene-3-carboxylate is used as an intermediate in organic syntheses | | Synthesis | Thirteen mL (200 mmol) of thionyl chloride was added slowly and dropwise at 0 °C to a 100 mL ethanol solution containing 9 g (70 mmol) of 3-thiophenecarboxylic acid and 86 mg (0.7 mmol) of 4-dimethylaminopyridine. The reaction mixture was gradually warmed from 0 °C to room temperature over 48 h with continuous stirring. Subsequently, the reaction solution was evaporated to dryness. The resulting residue was purified by silica column chromatography with the eluent being a 1:1 heptane/dichloromethane solvent mixture. Finally 10 g (91% yield) of ethyl thiophene-3-carboxylate was obtained. | | References | [1] Patent: WO2004/113331, 2004, A1. Location in patent: Page 38-39
[2] Organic Process Research and Development, 2017, vol. 21, # 7, p. 947 - 955
[3] Organic Letters, 2008, vol. 10, # 9, p. 1851 - 1854
[4] Angewandte Chemie - International Edition, 2017, vol. 56, # 33, p. 9924 - 9929
[5] Angew. Chem., 2017, vol. 129, p. 10056 - 10061,6 |
| | Ethyl thiophene-3-carboxylate Preparation Products And Raw materials |
|