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| | (5-Butanoate-1H-2-indolyl)(1H-2-indolyl)-methanone Basic information |
| Product Name: | (5-Butanoate-1H-2-indolyl)(1H-2-indolyl)-methanone | | Synonyms: | PDGF RECEPTOR TYROSINE KINASE INHIBITOR II;PDGFR Tyrosine Kinase Inhibitor II;D-65476;[2-(1H-2-INDOLYCARBONYL)-1H-5-INDOLYL]BUTANOATE;[2-(1H-2-INDOLYLCARBONYL)-1H-5-INDOLYL]BUTANOATE;Butanoic acid, 2-(1H-indol-2-ylcarbonyl)-1H-indol-5-yl ester;(5-Butanoate-1H-2-indolyl)(1H-2-indolyl)-methanone | | CAS: | 249762-74-1 | | MF: | C21H18N2O3 | | MW: | 346.38 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File |  |
| | (5-Butanoate-1H-2-indolyl)(1H-2-indolyl)-methanone Chemical Properties |
| storage temp. | 2-8°C | | solubility | DMSO: 5mg/mL | | form | solid | | color | yellow |
| WGK Germany | WGK 1 | | Storage Class | 11 - Combustible Solids |
| | (5-Butanoate-1H-2-indolyl)(1H-2-indolyl)-methanone Usage And Synthesis |
| Uses | D-65476 is an inhibitor of type Ⅲ receptor tyrosine kinase (Flt3). In the absence of IL-3, D-65476 inhibits the proliferation of TEL-Flt3 transfected BA/F3 cells (IC50= 0.2 μM), which can be used in the study of Flt3-driven leukemia[1]. | | Biological Activity | Cell permeable: yes', 'Primary Target
PDGFR in swiss 3T3 cells', 'Product competes with ATP.', 'Reversible: yes', 'Target IC50: 1.1 μM inhibiting PDGFR in swiss 3T3 cells; 6.2 μ M for hPDGFβ-R-mFlt3 and 50 nM in EOL-1 cells | | References | [1] Teller S, et al. Bis(1H-2-indolyl)-1-methanones as inhibitors of the hematopoietic tyrosine kinase Flt3. Leukemia. 2002;16(8):1528-1534. DOI:10.1038/sj.leu.2402630 |
| | (5-Butanoate-1H-2-indolyl)(1H-2-indolyl)-methanone Preparation Products And Raw materials |
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