- N-Methyl Desloratadine
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- $0.00 / 25kg
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2025-12-01
- CAS:38092-89-6
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 10000KGS
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| | N-Methyl Desloratadine Basic information |
| Product Name: | N-Methyl Desloratadine | | Synonyms: | 8-chloro-11-(1-methyl-4-piperidylidenel-5,11)-dihydro-5H-benzo5,6-cyclohepta;6,11ihydro-5H-Benzo-5,6Cyclohepta-L,2-BPyridine,Loratadine;8-Chloro-11-(1-Methyl-4-Piperidinylidene)-6, 11-dihydro 5H-Benzo [5,6] cyclohepta (1,2-b) Pyridine;6,11 –Dihydro- 5H- Benzo-5,6Cyclohepta- L,2-B Pyridine, Loratadine,;8-chloro-11-(1-methyl-4-piperidylidenel-5,11)-dihydro-5H-benzo〔5,6〕-cyclohepta〔1,2-b〕pyridine;8-CHLORO-6,11-DIHYDRO-11-(1-METHYL-4-PIPERIDINYLIDENE)-5H-BENZO[5,6] CYCLOHEPTA [1,2-B]PYRIDINE =99%;8-CHLORO-11-(L-METHYL-4-PIPERIDINYLIDENE-6,11-DIHYDRO-5H-BENZO[5.6])CYCLOHEPTA[L,2-B]PYRIDINE;8-CHLORO-11-(1-METHYL-4-PIPERIDYLIDENEL-5,11)-DIHYDRO-5H-BENZOK5,6L-CYCLOHEPTA | | CAS: | 38092-89-6 | | MF: | C20H21ClN2 | | MW: | 324.85 | | EINECS: | 641-012-1 | | Product Categories: | Intermediates & Fine Chemicals;Pharmaceuticals;(intermediate of loratadine);Chemical Amines;Amines;Aromatics;Heterocycles;Intermediates;Intermediate | | Mol File: | 38092-89-6.mol |  |
| | N-Methyl Desloratadine Chemical Properties |
| Melting point | 106-109°C | | Boiling point | 474.3±45.0 °C(Predicted) | | density | 1.205±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | 8.67±0.20(Predicted) | | Appearance | White to off-white Solid | | InChI | InChI=1S/C20H21ClN2/c1-23-11-8-14(9-12-23)19-18-7-6-17(21)13-16(18)5-4-15-3-2-10-22-20(15)19/h2-3,6-7,10,13H,4-5,8-9,11-12H2,1H3 | | InChIKey | VLXSCTINYKDTKR-UHFFFAOYSA-N | | SMILES | C12/C(=C3\CCN(C)CC\3)/C3=CC=C(Cl)C=C3CCC1=CC=CN=2 | | CAS DataBase Reference | 38092-89-6(CAS DataBase Reference) |
| | N-Methyl Desloratadine Usage And Synthesis |
| Chemical Properties | Red Oil | | Uses | An intermediate in the synthesis of Loratadine. Loratadine impurity. | | Uses | N-Methyl Desloratadine (Loratadine EP Impurity G; Loratadine USP Related Compound B) is an intermediate in the synthesis of Loratadine. Loratadine impurity. | | Synthesis | The general procedure for the synthesis of 8-chloro-11-(1-methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1 ,2-b]pyridine using (1-methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridin-2-yl]methanone hydrochloride as a starting material was as follows: in Example 2, the preparation of 8-chloro-6,11-dihydro-1H -(N-methyl-4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine (XII). This was done by preparing Compound XIII (100 g) according to the standard method described in U.S. Patent No. 4,659,716 by first azeotropic de-watering in toluene without drying. Subsequently, boric acid (115 g) and concentrated sulfuric acid (415 g) were added and the reaction was heated at 105-110°C for 4-8 hours. After completion of the reaction, the reaction mixture was slowly poured into cold water and extracted with ethyl acetate. Finally, the solvent was removed by distillation under reduced pressure to afford the target product 8-chloro-11-(1-methylpiperidin-4-ylmethylene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine as a solid form in 85% yield and 99.5% purity (determined by OAB and HPLC). | | References | [1] Journal of Organic Chemistry, 1989, vol. 54, # 9, p. 2242 - 2244
[2] Patent: WO2006/6184, 2006, A2. Location in patent: Page/Page column 17
[3] Patent: US6075025, 2000, A
[4] Patent: US6075025, 2000, A
[5] Patent: US5422351, 1995, A |
| | N-Methyl Desloratadine Preparation Products And Raw materials |
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