- H-L-Glu(OtBu)-OH
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- $0.00 / 1kg
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2026-04-03
- CAS:2419-56-9
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1T+
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| | L-Glutamic acid 5-tert-butyl ester Basic information |
| | L-Glutamic acid 5-tert-butyl ester Chemical Properties |
| Melting point | 182°C(lit.) | | Boiling point | 110 °C(Press: 0.05 Torr) | | density | 0.992 g/cm3 | | storage temp. | 2-8°C | | solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | | pka | 2.20±0.10(Predicted) | | form | Solid | | color | White to Almost white | | Water Solubility | Sparingly soluble in water; practically insoluble in ethanol or ether. | | BRN | 2049031 | | Major Application | peptide synthesis | | InChI | InChI=1S/C9H17NO4/c1-9(2,3)14-7(11)5-4-6(10)8(12)13/h6H,4-5,10H2,1-3H3,(H,12,13)/t6-/m0/s1 | | InChIKey | OIOAKXPMBIZAHL-LURJTMIESA-N | | SMILES | C(O)(=O)[C@H](CCC(OC(C)(C)C)=O)N | | CAS DataBase Reference | 2419-56-9(CAS DataBase Reference) |
| Risk Statements | 22-24 | | Safety Statements | 22-24/25-25 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 29224999 | | Storage Class | 11 - Combustible Solids |
| | L-Glutamic acid 5-tert-butyl ester Usage And Synthesis |
| Chemical Properties | White powder crystal | | Uses | L-Glutamic acid 5-tert-butyl ester is used as a fine chemical intermediate, pharmaceutical intermediate. | | reaction suitability | reaction type: solution phase peptide synthesis | | Synthesis | In a 3000mL three-necked flask, 2324g of tert-butyl acetate and 73.5g of glutamic acid were added, stirred, and was added dropwise.
160.8 mL of perchloric acid, react for 48 hours at 10C, cool down to 0C, add 1000 mL of water, extract
(the remaining tert-butyl acetate was used as solvent extraction), neutralized with Na2CO3 to pH=8 to 9, partitioned, and then extracted with
400 mL of 1% Na2CO3 aqueous solution was washed three times, and the tert-butyl acetate layer was concentrated under reduced pressure to give 42 g of Glu(OtBu)2 as an oil in 32.4% yield. In a 1000 mL three-necked flask, 42 g of Glu(OtBu)2 was added, 400 mL of water and 11 g of CuCl2 were added, .
The temperature was raised to 50 C and the reaction was carried out for 12 h to produce Cu[Glu(OtBu)]x (x=1-2); then it was lowered to room temperature and was added
19g tetramethylethylenediamine and 100mL dioxane, and then adjust the pH to 8~9 with triethylamine to produce L-glutamic acid-5-tert-butyl ester. |
| | L-Glutamic acid 5-tert-butyl ester Preparation Products And Raw materials |
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