4-Amino-1-Boc-piperidine

4-Amino-1-Boc-piperidine Basic information

Product Name:	4-Amino-1-Boc-piperidine
Synonyms:	1-PIPERIDINECARBOXYLIC ACID, 4-AMINO-,1,1-DIMETHYLETHYL ESTER;1-N-BOC-4-AMINOPIPERIDINE;1-T-BUTOXYCARBONYL-4-AMINOPIPERIDINE;1-tert-Butoxycarbonyl-4-amino-piperidine;1-BOC-4-PIPERIDINAMINE;1-BOC-4-AMINOPIPERIDINE;1-BUTYLOXYCARBONYL-4-AMINO-PIPERIDINE;4-AMINO-1-BOC-PIPERIDINE
CAS:	87120-72-7
MF:	C10H20N2O2
MW:	200.28
EINECS:	1312995-182-4
Product Categories:	Piperazine;Pyrans, Piperidines & Piperazines;Piperidines, Piperidones, Piperazines;Amines;blocks;pharmacetical;Pyrans, Piperidines &Piperazines;API intermediates;Piperidines;Amines and Anilines;AMINOACID;87120-72-7
Mol File:	87120-72-7.mol

4-Amino-1-Boc-piperidine Chemical Properties

Melting point	50°C
Boiling point	80/0.037mm
density	1.041±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
pka	10.10±0.20(Predicted)
form	Crystalline Powder, Crystals and/or Chunks
color	White to pale yellow to beige
Water Solubility	Insoluble in water.
Sensitive	Air Sensitive
InChI	InChI=1S/C10H20N2O2/c1-10(2,3)14-9(13)12-6-4-8(11)5-7-12/h8H,4-7,11H2,1-3H3
InChIKey	LZRDHSFPLUWYAX-UHFFFAOYSA-N
SMILES	N1(C(OC(C)(C)C)=O)CCC(N)CC1
CAS DataBase Reference	87120-72-7(CAS DataBase Reference)

Safety Information

MSDS Information

Provider	Language
SigmaAldrich	English

4-Amino-1-Boc-piperidine Usage And Synthesis

Chemical Properties	white to light yellow crystal powder
Uses	4-Amino-1-Boc-piperidine is a chemical reagent used in the preparation of pharmaceutical compounds. Used in the synthesis of bromodomain inhibitors as well as HepG2 cell cycle inhibitors used in anti-tumor therapy. Also employed in a microwave-assisted solid-phase synthesis of N-substituted piperidines via direct annulation of primary amines with resin-bound dimesylates.
Uses	4-Amino-1-Boc-piperidine is a potent inhibitor of the CCR5 receptor. It is an x-ray crystal structure with a hydroxide solution that inhibits the growth of cancer cells. The inhibitor binding site for 4-Amino-1-Boc-piperidine was determined to be the CCR5 receptor, which is located on the surface of hematopoietic cells. The compound has been shown to inhibit human T lymphocyte proliferation in vitro and inhibit HIV replication in infected patients. 4-Amino-1-Boc-piperidine is able to inhibit the growth of cancer cells by blocking the production of cytokines, such as interleukin 2, that are needed for cell division and growth.
Application	4-Amino-1-Boc-piperidine is a pharmaceutical intermediate is applied in the treatment of anti-tumor and other drugs. It is an important fine chemical intermediate and has a wide range of uses in the pharmaceutical industry.

4-Amino-1-Boc-piperidine Preparation Products And Raw materials

Raw materials	Ethanol-->Sodium hydroxide-->Methanol-->Tetrahydrofuran-->Dichloromethane-->Sodium-->Triethylamine-->Ammonium hydroxide-->Ammonia-->Palladium-->1,4-Dioxane-->Di-tert-butyl dicarbonate-->Tosyl chloride-->4,4-Piperidinediol hydrochloride-->N-BOC-4-Hydroxypiperidine
Preparation Products	tert-butyl (3S,4R)-4-aMino-3-fluoropiperidine-1-carboxylate-->tert-butyl 4-nitropiperidine-1-carboxylate-->1-ISOPROPYL-PIPERIDIN-4-YLAMINE

Tag:4-Amino-1-Boc-piperidine(87120-72-7) Related Product Information

1-Aminopiperidine 4-Aminoantipyrine Glycine 4-Dimethylaminopyridine DROPERIDOL 4,4'-Diaminodiphenylsulfone Haloperidol 1-Boc-4-Methylaminopiperidine 4-N-BOC-Aminopiperidine ALTRENOGEST N-BOC-3-Aminopiperidine DI-TERT-BUTYL ETHER Ethyl N-Boc-piperidine-2-carboxylate 1-BOC-3-PIPERIDINECARBOXALDEHYDE N-Boc-4-piperidinemethanol (+/-)-1-N-BOC-PIPERIDINE-2-CARBOXAMIDE 1-tert-Butoxycarbonyl-4-piperidinecarboxaldehyde N-BOC-piperidine-4-carboxylic acid

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