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| | Sulfamonomethoxine Basic information |
| | Sulfamonomethoxine Chemical Properties |
| Melting point | 203-2060C | | Boiling point | 513℃ | | density | 1.3936 (rough estimate) | | refractive index | 1.6200 (estimate) | | Fp | >110°(230°F) | | storage temp. | Keep in dark place,Inert atmosphere,2-8°C | | solubility | methanol: soluble10mg/mL | | pka | pKa 5.94 (Uncertain) | | form | powder | | color | white to white with yellow cast | | Water Solubility | Soluble in water at 10mg/ml with warming. Also soluble in ethanol or methanol | | BRN | 621128 | | Major Application | clinical testing | | InChI | InChI=1S/C11H12N4O3S/c1-18-11-6-10(13-7-14-11)15-19(16,17)9-4-2-8(12)3-5-9/h2-7H,12H2,1H3,(H,13,14,15) | | InChIKey | WMPXPUYPYQKQCX-UHFFFAOYSA-N | | SMILES | C1(S(NC2C=C(OC)N=CN=2)(=O)=O)=CC=C(N)C=C1 | | CAS DataBase Reference | 1220-83-3(CAS DataBase Reference) | | EPA Substance Registry System | Sulfamonomethoxine (1220-83-3) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38-43 | | Safety Statements | 26-36 | | WGK Germany | 2 | | RTECS | WP0550000 | | HazardClass | IRRITANT | | HS Code | 29350090 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
Skin Sens. 1
STOT SE 3 | | Toxicity | LD50 oral in rabbit: > 10gm/kg |
| | Sulfamonomethoxine Usage And Synthesis |
| Chemical Properties | White To Off-White Crystalline Powder | | Uses | antibacterial | | Uses | Protein binding. Inhibitor of enzyme. Sulfamonomethoxine and Trimethoprim are used for treating porcine unknown hyperpyrexia. | | Definition | ChEBI: Sulfamonomethoxine is a sulfonamide and a member of benzenes. | | Synthesis Reference(s) | The Journal of Organic Chemistry, 26, p. 2764, 1961 DOI: 10.1021/jo01066a034 | | General Description | Chemical structure: sulfonamide | | Biochem/physiol Actions | Sulfamonomethoxine is a competitive inhibitor of dihydropteroate synthetase used to block the synthesis of folic acid. | | Synthesis | Sodium sulfamethoxazole is commonly used in clinical practice, and the preparation method of sodium sulfamethoxazole includes the following steps:
(1) Add sulfamethoxazole and sodium hydroxide into organic solvent, and stir the reaction for 0.5-2 hours under the temperature condition of 54-98 to get solution A;
(2) add activated carbon to solution A, stir to decolorize for 0.3-0.8 hours, filter while hot, get filtrate;
(3) The filtrate was first naturally cooled to 20-30 , and then at 0-5 , holding temperature for 1-3 hours, filtration, to get the filtrate residue;
(4) Wash the filtrate with a small amount of anhydrous ethanol, and dry in vacuum at 55~60 for 2-4 hours, to get sodium sulfamethoxymethane.
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| | Sulfamonomethoxine Preparation Products And Raw materials |
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