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TERT-BUTYL 8-BROMO-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE

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Products Intro: Product Name:tert-butyl 8-bromo-3,4-dihydroisoquinoline-2(1H)-carboxylate
CAS:893566-75-1
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
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Products Intro: Product Name:2-Boc-8-bromo-1,2,3,4-tetrahydroisoquinoline
CAS:893566-75-1
Purity:>=98% Package:0.1g;0.25g;1g;5g;10g;25g;100g
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Products Intro: Product Name:tert-butyl 8-bromo-3,4-dihydroisoquinoline-2(1H)-carboxylate
CAS:893566-75-1
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Products Intro: Product Name:TERT-BUTYL 8-BROMO-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE
CAS:893566-75-1
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Products Intro: Product Name:TERT-BUTYL 8-BROMO-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE
CAS:893566-75-1
Purity:0 Package:1g; 5g; 25g; 1kg; 5kg; 25kg Remarks:0

TERT-BUTYL 8-BROMO-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE manufacturers
TERT-BUTYL 8-BROMO-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE Basic information
Product Name:TERT-BUTYL 8-BROMO-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE
Synonyms:TERT-BUTYL 8-BROMO-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE;2-BOC-8-BROMO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE;N-BOC-1,2,3,4-tetrahydro-8-broMo-isoquinoline;2(1H)-Isoquinolinecarboxylic acid, 8-bromo-3,4-dihydro-, 1,1-dimethylethyl ester;N-Boc-8-Bromo-1,2,3,4-tetrahydroisoquinoline
CAS:893566-75-1
MF:C14H18BrNO2
MW:312.2
EINECS:
Product Categories:
Mol File:893566-75-1.mol
TERT-BUTYL 8-BROMO-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE Structure
TERT-BUTYL 8-BROMO-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE Chemical Properties
Boiling point 382.4±42.0 °C(Predicted)
density 1.353±0.06 g/cm3(Predicted)
storage temp. 2-8°C
pka-1.60±0.20(Predicted)
AppearanceWhite to off-white Solid
Safety Information
MSDS Information
TERT-BUTYL 8-BROMO-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE Usage And Synthesis
Usestert-Butyl 8-Bromo-3,4-dihydroisoquinoline-2(1H)-carboxylate is an Amide compound; having BET proteolysis-inducing action, and medicinal application thereof.
Synthesis
Di-tert-butyl dicarbonate

24424-99-5

8-bromo-1,2,3,4-tetrahydroisoquinoline

75416-51-2

TERT-BUTYL 8-BROMO-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE

893566-75-1

Di-tert-butyl dicarbonate (Boc2O, 25.73 g, 117.88 mmol) was added slowly and dropwise at 0 °C to dichloromethane (DCM, containing 8-bromo-1,2,3,4-tetrahydroisoquinoline (Intermediate 21, 25.00 g, 117.88 mmol) and triethylamine (TEA, 32.83 mL, 236.00 mmol) in a 300 mL) solution. The reaction mixture was stirred continuously for 30 minutes at room temperature. Upon completion of the reaction, citric acid solution was added to quench the reaction, followed by a layering operation. The organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate, 3/1, v/v) to afford N-boc-8-bromo-1,2,3,4-tetrahydroisoquinoline (Intermediate 22, 35 g, 95% yield).

References[1] Patent: WO2017/216293, 2017, A1. Location in patent: Page/Page column 74; 75
Tag:TERT-BUTYL 8-BROMO-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE(893566-75-1) Related Product Information
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