| Company Name: |
BOC Sciences |
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1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
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| | MCL-1/BCL-2-IN-1 Basic information |
| Product Name: | MCL-1/BCL-2-IN-1 | | Synonyms: | MCL-1/BCL-2-IN-1;Benzamide, N-[2-[6-[(4-bromophenyl)thio]-1,3-dioxo-1H-benz[de]isoquinolin-2(3H)-yl]ethyl]-4-(1,1-dimethylethyl)- | | CAS: | 2493256-46-3 | | MF: | C31H27BrN2O3S | | MW: | 587.53 | | EINECS: | | | Product Categories: | | | Mol File: | 2493256-46-3.mol |  |
| | MCL-1/BCL-2-IN-1 Chemical Properties |
| Melting point | 244-246 °C | | Boiling point | 770.940±60.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.469±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | form | Solid | | pka | 14.445±0.46(predicted) | | color | Light yellow to yellow |
| | MCL-1/BCL-2-IN-1 Usage And Synthesis |
| Uses | MCL-1/BCL-2-IN-2 (Compound Nap-1) is a potent and selective Mcl-1 and Bcl-2 dual inhibitor with IC50s of 4.45 and 3.18 μM, respectively[1]. | | IC 50 | Mcl-1: 4.45 μM (IC50); Bcl-2: 3.18 μM (IC50) | | References | [1] Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Sep 12;62(17):8152-8163. DOI:10.1021/acs.jmedchem.9b00919 |
| | MCL-1/BCL-2-IN-1 Preparation Products And Raw materials |
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