| Company Name: |
Sichuan Wei Keqi Biological Technology Co., Ltd.
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| Tel: |
028-81700200 18116577057 |
| Email: |
3003855609@qq.com |
| Products Intro: |
Product Name:K-Rasligand-LinkerConjugate4
CAS:2378261-83-5
Purity:98% Package:5mg；10mg；20mg；50mg；100mg；200mg；500mg；1g
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K-Ras ligand-Linker Conjugate 4 manufacturers
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| | K-Ras ligand-Linker Conjugate 4 Basic information |
| Product Name: | K-Ras ligand-Linker Conjugate 4 | | Synonyms: | K-Ras ligand-Linker Conjugate 4;1-Piperazinecarboxylic acid, 2-(cyanomethyl)-4-[5,6,7,8-tetrahydro-2-[[(2S,4R)-4-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]-1-methyl-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidin-4-yl]-, phenylmethyl ester, (2S)- | | CAS: | 2378261-83-5 | | MF: | C35H51N7O8 | | MW: | 697.82 | | EINECS: | | | Product Categories: | | | Mol File: | 2378261-83-5.mol |  |
| | K-Ras ligand-Linker Conjugate 4 Chemical Properties |
| Boiling point | 861.9±75.0 °C(Predicted) | | density | 1.30±0.1 g/cm3(Predicted) | | pka | 14.36±0.10(Predicted) | | form | Oil | | color | Colorless to light yellow |
| | K-Ras ligand-Linker Conjugate 4 Usage And Synthesis |
| Uses | K-Ras ligand-Linker Conjugate 4 incorporates a ligand for K-Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 4 can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells[1]. | | References | [1] CREW, Andrew P., et al. MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE. WO2019195609A2. |
| | K-Ras ligand-Linker Conjugate 4 Preparation Products And Raw materials |
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