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| | Hepcidin-20 (human) Basic information |
| Product Name: | Hepcidin-20 (human) | | Synonyms: | Hepcidin-20 (human);L-Threonine, L-isoleucyl-L-cysteinyl-L-isoleucyl-L-phenylalanyl-L-cysteinyl-L-cysteinylglycyl-L-cysteinyl-L-cysteinyl-L-histidyl-L-arginyl-L-seryl-L-lysyl-L-cysteinylglycyl-L-methionyl-L-cysteinyl-L-cysteinyl-L-lysyl-, cyclic (2→8),(5→18),(6→17),(9→14)-tetrakis(disulfide) | | CAS: | 342790-23-2 | | MF: | C85H135N27O23S9 | | MW: | 2191.75 | | EINECS: | | | Product Categories: | | | Mol File: | 342790-23-2.mol |  |
| | Hepcidin-20 (human) Chemical Properties |
| density | 1.60±0.1 g/cm3(Predicted) | | pka | 3.21±0.10(Predicted) | | Sequence | H-Ile-Cys-Ile-Phe-Cys-Cys-Gly-Cys-Cys-His-Arg-Ser-Lys-Cys-Gly-Met-Cys-Cys-Lys-Thr-OH(Disulfide bonds, air oxidized) |
| | Hepcidin-20 (human) Usage And Synthesis |
| Uses | Hepcidin-20 (human) is a histidine-containing, cysteine-rich, β-sheet structured peptide. Hepcidin-20 (human) shows antifungal activity. Hepcidin-20 (human) inhibits biofilm formation and bacterial cell metabolism of polysaccharide intercellular adhesin (PIA)-positive and PIA-negative strains[1][2][3]. | | References | [1] Maisetta G, et al. pH-dependent disruption of Escherichia coli ATCC 25922 and model membranes by the human antimicrobial peptides hepcidin 20 and 25. FEBS J. 2013 Jun;280(12):2842-54. DOI:10.1111/febs.12288
[2] Del Gaudio G, et al. Antifungal Activity of the Noncytotoxic Human Peptide Hepcidin 20 against Fluconazole-Resistant Candida glabrata in Human Vaginal Fluid. Antimicrob Agents Chemother. 2013 Sep;57(9):4314-4321. DOI:10.1128/AAC.00904-13
[3] Brancatisano FL, et al. Inhibitory effect of the human liver-derived antimicrobial peptide hepcidin 20 on biofilms of polysaccharide intercellular adhesin (PIA)-positive and PIA-negative strains of Staphylococcus epidermidis. Biofouling. 2014;30(4):435-46. DOI:10.1080/08927014.2014.888062 |
| | Hepcidin-20 (human) Preparation Products And Raw materials |
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