1,6-Naphthyridine-6(5H)-carboxamide, N-[2-(4-fluorophenoxy)-5-pyrimidinyl]-5-(4-fluorophenyl)-7,8-dihydro-, (5S)-

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1,6-Naphthyridine-6(5H)-carboxamide, N-[2-(4-fluorophenoxy)-5-pyrimidinyl]-5-(4-fluorophenyl)-7,8-dihydro-, (5S)- manufacturers

  • BAY-899
  • BAY-899 pictures
  • $4700.00
  • 2026-05-21
  • CAS:2471967-92-5
  • Purity:
  • Supply Ability: 10g
1,6-Naphthyridine-6(5H)-carboxamide, N-[2-(4-fluorophenoxy)-5-pyrimidinyl]-5-(4-fluorophenyl)-7,8-dihydro-, (5S)- Basic information
Product Name:1,6-Naphthyridine-6(5H)-carboxamide, N-[2-(4-fluorophenoxy)-5-pyrimidinyl]-5-(4-fluorophenyl)-7,8-dihydro-, (5S)-
Synonyms:1,6-Naphthyridine-6(5H)-carboxamide, N-[2-(4-fluorophenoxy)-5-pyrimidinyl]-5-(4-fluorophenyl)-7,8-dihydro-, (5S)-;(5S)-N-[2-(4-fluorophenoxy)pyrimidin-5-yl]-5-(4-fluorophenyl)-5,6,7,8-tetrahydro-1,6-naphthyridine-6-carboxamide;BAY-899
CAS:2471967-92-5
MF:C25H19F2N5O2
MW:459.45
EINECS:
Product Categories:APIs
Mol File:2471967-92-5.mol
1,6-Naphthyridine-6(5H)-carboxamide, N-[2-(4-fluorophenoxy)-5-pyrimidinyl]-5-(4-fluorophenyl)-7,8-dihydro-, (5S)- Structure
1,6-Naphthyridine-6(5H)-carboxamide, N-[2-(4-fluorophenoxy)-5-pyrimidinyl]-5-(4-fluorophenyl)-7,8-dihydro-, (5S)- Chemical Properties
density 1.397±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: 1mg/mL, clear
pka12.52±0.40(Predicted)
form Solid
color White to off-white
Optical Rotation[α]/D 165 to 195°, c =1 in chloroform-d
InChIKeyVKQBTIMLSDGNLG-QHCPKHFHSA-N
SMILESO=C(N1[C@@H](C2=CC=C(F)C=C2)C3=C(N=CC=C3)CC1)NC4=CN=C(OC5=CC=C(F)C=C5)N=C4
Safety Information
WGK Germany WGK 3
Storage Class11 - Combustible Solids
MSDS Information
1,6-Naphthyridine-6(5H)-carboxamide, N-[2-(4-fluorophenoxy)-5-pyrimidinyl]-5-(4-fluorophenyl)-7,8-dihydro-, (5S)- Usage And Synthesis
UsesBAY-899 is an orally active and selective luteinizing hormone receptor (LH-R) antagonist with IC50s of 185 nM and 46nM for hLH (human LH) and rLH (rat LH), respectively. BAY-899 can reduce sex hormone levels[1].
Biological ActivityBAY-899 is an orally available, potent and selective antagonist of the human luteinizing hormone receptor (hLH-R) th at reduces sex hormone levels in several animal models. BAY-899 likely binds to a putative rhodopsin-like binding cavity located within the 7-transmembrane region of the hLH-receptor.
in vivo

BAY-899 (oral; 12.5 mg/kg/day; for 8 days) shows an efficiency to reduce serum estradiol levels in intact female rats[1].
BAY-899 (iv of 0.5 mg/kg or po of 2 mg/kg) has a t1/2 of 11 hours and 12 hours for iv and po. And the Cmax is 0.97 kg/L and 0.24 kg/L for iv and po[1].

Animal Model:Intact female rats[1]
Dosage:12.5 mg/kg
Administration:Oral; for 8 days
Result:Showed an efficiency to reduce serum estradiol levels.
Animal Model:Female and male Wistar rats[1]
Dosage:0.5 mg/kg of iv or 2 mg/kg of po
Administration:Iv or po
Result:Has t1/2s of 11 hours and 12 hours for iv and po. And the Cmaxs are 0.97 kg/L and 0.24 kg/L for iv and po.
References[1] Wortmann L, et al. Discovery of BAY-298 and BAY-899: Tetrahydro-1,6-naphthyridine-Based, Potent and Selective Antagonists of the Luteinizing Hormone Receptor Which Reduce Sex Hormone Levels In Vivo. J Med Chem. 2019 Oct 31. DOI:10.1021/acs.jmedchem.9b01382
1,6-Naphthyridine-6(5H)-carboxamide, N-[2-(4-fluorophenoxy)-5-pyrimidinyl]-5-(4-fluorophenyl)-7,8-dihydro-, (5S)- Preparation Products And Raw materials
Tag:1,6-Naphthyridine-6(5H)-carboxamide, N-[2-(4-fluorophenoxy)-5-pyrimidinyl]-5-(4-fluorophenyl)-7,8-dihydro-, (5S)-(2471967-92-5) Related Product Information
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