| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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| Tel: |
18818260767 |
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sales@chemegen.com |
| Products Intro: |
Product Name:Nebentan potassium
CAS:342005-82-7
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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Nebentan potassium manufacturers
- Nebentan potassium
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- $84.00 / 1mg
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2024-11-20
- CAS:342005-82-7
- Min. Order:
- Purity: 98.92%
- Supply Ability: 10g
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| | Nebentan potassium Basic information |
| | Nebentan potassium Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO: 125 mg/mL (236.02 mM) | | form | Solid | | color | Off-white to light yellow |
| | Nebentan potassium Usage And Synthesis |
| Uses | Nebentan potassium (YM598) is a potent, selective and orally active non-peptide endothelin ETA receptor antagonist through the modification of Bosentan (HY-A0013). Nebentan potassium inhibits [125I] endothelin-1 binding to cloned human endothelin ETA and ETB receptor, with Ki of 0.697 nM and 569 nM, respectively[1]. YM598 can ameliorate the progression of cor pulmonale and myocardial infarction in vivo[2]. | | in vivo | Nebentan potassium (oral administration; 0.1-1 mg/kg; 4 weeks) significantly inhibits the progression of pulmonary hypertension and the development of right ventricular hypertrophy[2].Nebentan potassium (oral administration; 1 mg/kg; 30 weeks) significantly ameliorates the poor survival rate of CHF rats, it markedly reduces the hypertrophy of both ventricles as well as pulmonary congestion[2]. | | IC 50 | ETA: 0.679 nM (Ki); ETB: 569 nM (Ki) | | References | [1] Hironori Yuyama, et al. Pharmacological Characterization of YM598, an Orally Active and Highly Potent Selective Endothelin ET(A) Receptor Antagonist. Eur J Pharmacol. 2003 Sep 30;478(1):61-71. DOI:10.1016/j.ejphar.2003.08.031
[2] Akira Fujimori, et al. YM598, an Orally Active ET(A) Receptor Antagonist, Ameliorates the Progression of Cardiopulmonary Changes and Both-Side Heart Failure in Rats With Cor Pulmonale and Myocardial Infarction. J Cardiovasc Pharmacol. 2004 Nov;44 Suppl 1:S354-7. DOI:10.1097/01.fjc.0000166304.40937.0b |
| | Nebentan potassium Preparation Products And Raw materials |
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